Evidence map›Paper›PMID 41596291›Full record

ArticleInternational journal of molecular sciences2026

The Potential Link and Role of Zyxin in the Pathogenesis of Psoriasis and Its Associated Comorbidities.

Mateusz Matwiejuk, Agnieszka Kulczyńska-Przybik, Bartłomiej Łukaszuk, Hanna Myśliwiec, Piotr Myśliwiec, Adrian Chabowski, Barbara Mroczko, Iwona Flisiak

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mateusz MatwiejukDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-089 Białystok, Poland.ORCID 0000-0002-2873-4001
Agnieszka Kulczyńska-PrzybikDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
Bartłomiej ŁukaszukDepartment of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.ORCID 0000-0002-4954-3431
Hanna MyśliwiecDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-089 Białystok, Poland.ORCID 0000-0003-1948-0545
Piotr Myśliwiec1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, 15-276 Bialystok, Poland.
Adrian ChabowskiDepartment of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.ORCID 0000-0002-7407-8156
Barbara MroczkoDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.ORCID 0000-0002-4075-8479
Iwona FlisiakDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-089 Białystok, Poland.ORCID 0000-0002-5923-910X

Funding

Medical University of Bialystok B.SUB.24.230
6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory disorder with immunological, metabolic, and environmental components. It affects not only the skin but also the nails, joints, and vascular system. A total of 50 patients with psoriasis and 28 healthy controls took part in this study. Serum samples were gathered both from the psoriatic group and the control group. Serum zyxin concentrations were measured via enzyme-linked immunosorbent assay (ELISA). Our results revealed that serum zyxin amounts were significantly higher in patients with psoriasis compared with the controls. However, no statistically significant correlations were found between serum zyxin levels and inflammatory or metabolic parameters in the psoriasis group. Similarly, there was no significant correlation between zyxin level and disease severity as assessed by the Psoriasis Area and Severity Index (PASI) score. To sum up, our study demonstrates that serum zyxin levels are significantly elevated in patients with psoriasis compared with controls. Nevertheless, the precise role of zyxin in the aetiology of psoriasis remains unclear. Further research is needed to clarify the function of this protein in the disease process and to explore its potential as a therapeutic target.

Indexed as

PsoriasisZyxinAdultBiomarkersCase-Control StudiesComorbidityFemaleHumansMaleMiddle AgedSeverity of Illness IndexBiomarkersZyxinproteinpsoriasisskin diseaseszyxin

Identifiers

PMID41596291
PMCPMC12841012

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.