Evidence map›Paper›PMID 41596307›Full record

ArticleInternational journal of molecular sciences2026

Polydopamine-Coated Surfaces Promote Adhesion, Migration, Proliferation, Chemoresistance, Stemness, and Epithelial-Mesenchymal Transition of Human Prostate Cancer Cell Lines In Vitro via Integrin α

Won Hoon Song, Ji-Eun Kim, Lata Rajbongshi, Su-Rin Lee, Yuna Kim, Seon Yeong Hwang, Sae-Ock Oh, Byoung Soo Kim, Dongjun Lee, Sik Yoon

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Won Hoon SongDepartment of Urology, Pusan National University Yangsan Hospital, Pusan National University College of Medicine, Yangsan 626-870, Republic of Korea.ORCID 0000-0003-1930-6045
Ji-Eun KimDepartment of Anatomy, Pusan National University College of Medicine, Yangsan 50612, Republic of Korea.
Lata RajbongshiDepartment of Anatomy, Pusan National University College of Medicine, Yangsan 50612, Republic of Korea.ORCID 0009-0002-1980-1871
Su-Rin LeeDepartment of Anatomy, Pusan National University College of Medicine, Yangsan 50612, Republic of Korea.
Yuna KimSchool of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Seon Yeong HwangDepartment of Anatomy, Pusan National University College of Medicine, Yangsan 50612, Republic of Korea.ORCID 0000-0002-6198-5742
Sae-Ock OhDepartment of Anatomy, Pusan National University College of Medicine, Yangsan 50612, Republic of Korea.
Byoung Soo KimSchool of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0002-6693-0003
Dongjun LeeDepartment of Convergence Medicine, Pusan National University College of Medicine, Yangsan 50612, Republic of Korea.ORCID 0000-0001-6828-401X
Sik YoonDepartment of Anatomy, Pusan National University College of Medicine, Yangsan 50612, Republic of Korea.ORCID 0000-0002-6449-0761

Funding

The National Research Foundation of Korea (NRF) and Korean government (MSIT), & 2025 BK21 FOUR Graduate School Innovation Support funded by Pusan National University (PNU-Fellowship program) RS-2022-NR070846 and RS-2025-24534285),
6 · The paper itself

Abstract

Polydopamine (PDA) surface coatings are widely used in biomedical engineering to enhance cell-substrate interactions; however, their effects on cancer-cell behavior remain unclear. In this study, we investigated how PDA-coated two-dimensional (2D) culture surfaces influence oncogenic traits of human prostate cancer (PC) cells in vitro. Using LNCaP, DU145, and PC3 cell lines, we found that PDA-coated substrates markedly increased the adhesion, migration, invasion, proliferation, and colony formation in a dose- and time-dependent manner. PDA exposure also induced epithelial-mesenchymal transition (EMT), upregulated cancer stem cell markers (

Indexed as

Drug Resistance, NeoplasmEpithelial-Mesenchymal TransitionIndolesIntegrin alpha2beta1Neoplastic Stem CellsPolymersProstatic NeoplasmsCell AdhesionCell Line, TumorCell MovementCell ProliferationFocal Adhesion Kinase 1HumansMaleMAP Kinase Signaling SystemSignal TransductionFocal Adhesion Kinase 1IndolesIntegrin alpha2beta1polydopaminePolymersPTK2 protein, humanadhesionchemoresistanceepithelial–mesenchymal transitionFAK–JNK signalingmigrationpolydopamineproliferationprostate cancerstemness

Identifiers

PMID41596307
PMCPMC12841494

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.