Analysis of Soft Tissue N-Glycome Profiles in Oral Squamous Cell Carcinoma, a Pilot Study.

Eniko Gebri, Kinga Hogyor, Adrienne Szabo, Andras Guttman

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eniko GebriDepartment of Oral Medicine, Faculty of Dentistry, University of Debrecen, H-4032 Debrecen, Hungary.

Kinga HogyorTranslational Glycomics Group, Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, H-8200 Veszprem, Hungary.

Adrienne SzaboDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-0135-739X

Andras GuttmanTranslational Glycomics Group, Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, H-8200 Veszprem, Hungary.ORCID 0000-0002-7838-082X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is an aggressive disease with a glycoproteomically unmapped progression and a low five-year survival rate. Thus, the aim of this pilot study was to explore the N-glycosylation pattern differences in malignant, adjacent mucosal and healthy tissues in the context of OSCC. Oral mucosal soft tissue samples was obtained by incisional biopsy from five patients with OSCC, both from the malignant and the opposite healthy gingival sides, and from seven age-sex-matched healthy controls. The collected tissues were homogenized, followed by N-glycan profiling of the endoglycosidase-released and fluorophore-labeled carbohydrates using capillary electrophoresis with ultra-sensitive laser-induced fluorescent detection (CE-LIF). Six out of the twenty-two identified N-glycan structures, including glycogens, showed significant (

Indexed as

Carcinoma, Squamous CellGlycomicsMouth NeoplasmsPolysaccharidesAgedCase-Control StudiesElectrophoresis, CapillaryFemaleGlycosylationHumansMaleMiddle AgedMouth MucosaPilot ProjectsPolysaccharidesbiomarkerscapillary electrophoresisglycogensN-glycomeoral squamous cell carcinoma

Identifiers

PMID41596390

DOI10.3390/ijms27020740

PMCPMC12841353

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.