Integrative Network Analysis of Single-Cell RNA Findings and a Priori Knowledge Highlights Gene Regulators in Multiple Myeloma Progression.

Grigoris Georgiou, Margarita Zachariou, George M Spyrou

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Grigoris GeorgiouBioinformatics Department, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, 2370 Nicosia, Cyprus.ORCID 0009-0006-7229-3617

Margarita ZachariouBioinformatics Department, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, 2370 Nicosia, Cyprus.ORCID 0000-0001-8950-4077

George M SpyrouBioinformatics Department, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, 2370 Nicosia, Cyprus.ORCID 0000-0002-2470-3363

Funding

European Union 101097094

6 · The paper itself

Abstract

Multiple Myeloma (MM) is an incurable malignancy that progresses from asymptomatic precursor stages-Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smouldering Multiple Myeloma (SMM)-to active disease. Despite ongoing research, the molecular mechanisms driving this progression remain poorly understood. In this study, we aimed to uncover key regulatory factors involved in MM progression by integrating single-cell RNA sequencing (scRNA-seq) data with curated a priori biological knowledge of MM. To this end, we first integrated a priori knowledge from databases in a synthetic gene network map to play the role of an MM-related backbone to project findings from scRNA analysis on CD138

Indexed as

Gene Expression Regulation, NeoplasticGene Regulatory NetworksMultiple MyelomaSingle-Cell AnalysisDisease ProgressionGene Expression ProfilingHumansSingle-Cell Gene Expression AnalysiscancermalignancyMultiple Myelomanetwork analysisnetwork integrationplasma cellsregulationscRNA

Identifiers

PMID41596441

DOI10.3390/ijms27020793

PMCPMC12840655

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.