Evidence map›Paper›PMID 41596471›Full record

ArticleInternational journal of molecular sciences2026

P-Element-Induced Wimpy Testis (PIWI)-Interacting RNA-823/PIWIL1/DNMT3B/CDH1 as Potential Axis to Drive EMT, Stemness, and Tumor Aggressiveness in Ovarian Cancer Tissue Samples: An Integrative Computational and Clinical Insights.

Fatma H Shaker, Eman F Sanad, Nader M Ibrahim, Hesham Elghazaly, Shih-Min Hsia, Nadia M Hamdy

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fatma H ShakerDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0003-0586-2147
Eman F SanadDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0001-5406-2029
Nader M IbrahimDepartment of Gynecology and Obstetrics, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Hesham ElghazalyDepartment of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-9327-286X
Shih-Min HsiaSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110301, Taiwan.ORCID 0000-0003-2888-2618
Nadia M HamdyDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0003-2105-107X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) remains the leading cause of death among gynecologic cancers. Most women diagnosed with OC at advanced stages eventually develop relapse and chemoresistance, leading to poor clinical outcomes. While piRNAs have emerged as critical regulators of gene expression and tumor biology, their specific roles in OC remain to be fully elucidated. This study integrated clinical and computational analyses to investigate the expression pattern and functional relevance of P-element-induced wimpy testis (PIWI)-interacting RNA-823 (piR-823) and its associated protein piwi-like RNA-mediated gene silencing 1 (PIWIL1)/DNA methyltransferase 3B (DNMT3B)/E-cadherin (CDH1) axis in OC tissues from 40 patients, with 20 non-cancer control samples. Expression profiling was performed using qPCR on OC and normal ovarian tissues, followed by correlation and regression analyses. Public databases, including GEPIA, TNM plot, and MethBank, were explored to validate gene expression, methylation status, and pathway enrichment. Our results revealed that piR-823, PIWIL1, and DNMT3B were significantly upregulated in OC tissues (

Indexed as

Antigens, CDArgonaute ProteinsCadherinsDNA (Cytosine-5-)-MethyltransferasesEpithelial-Mesenchymal TransitionNeoplastic Stem CellsOvarian NeoplasmsPiwi-Interacting RNADNA MethylationDNA Methyltransferase 3BFemaleGene Expression Regulation, NeoplasticHumansAntigens, CDArgonaute ProteinsCadherinsCDH1 protein, humanDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BPiwi-Interacting RNAPIWIL1 protein, humanbioinformaticsDNA methyltransferase 3B (DNMT3B)E-cadherin (CDH1)epithelial–mesenchymal transition (EMT)in silico analysesNANOGN-cadherin (CDH2)OCT4ovarian cancer (OC)P-element-induced wimpy testis (PIWI)-interacting RNA-823 (piR-823)PIWIL1

Identifiers

PMID41596471
PMCPMC12841119

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.