Evidence map›Paper›PMID 41597202›Full record

ArticleCells2026

Targeting of Human Mitochondrial DNA with Programmable pAgo Nuclease.

Beatrisa Rimskaya, Ekaterina Kropocheva, Elza Shchukina, Egor Ulashchik, Daria Gelfenbein, Lidiya Lisitskaya, Vadim Shmanai, Svetlana Smirnikhina, Andrey Kulbachinskiy, Ilya Mazunin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Beatrisa RimskayaMoscow Center for Advanced Studies, 123592 Moscow, Russia.ORCID 0000-0003-2186-5823
Ekaterina KropochevaThe Center for Bio- and Medical Technologies, 121205 Moscow, Russia.
Elza ShchukinaMoscow Center for Advanced Studies, 123592 Moscow, Russia.ORCID 0009-0003-5351-2835
Egor UlashchikInstitute of Physical Organic Chemistry, National Academy of Science of Belarus, 220072 Minsk, Belarus.ORCID 0000-0002-6617-4375
Daria GelfenbeinInstitute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Lidiya LisitskayaInstitute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-5283-7983
Vadim ShmanaiInstitute of Physical Organic Chemistry, National Academy of Science of Belarus, 220072 Minsk, Belarus.ORCID 0000-0003-1775-8101
Svetlana SmirnikhinaResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Andrey KulbachinskiyInstitute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Ilya MazuninThe Center for Bio- and Medical Technologies, 121205 Moscow, Russia.ORCID 0000-0002-5448-9679

Funding

Russian Science Foundation 25-24-00078
6 · The paper itself

Abstract

Manipulating the mitochondrial genome remains a significant challenge in genetic engineering, primarily due to the mitochondrial double-membrane structure. While recent advances have expanded the genetic toolkit for nuclear and cytoplasmic targets, precise editing of mitochondrial DNA (mtDNA) has remained elusive. Here we report the first successful mitochondrial import of a catalytically active RNA-guided prokaryotic Argonaute protein from the mesophilic bacterium

Indexed as

Argonaute ProteinsDNA, MitochondrialHumansMitochondriaArgonaute ProteinsDNA, MitochondrialDNA editingmitochondriamtDNA copy numberprokaryotic Argonaute proteins

Identifiers

PMID41597202
PMCPMC12839139

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.