Evidence map›Paper›PMID 41597240›Full record

ArticleCells2026

Western Diet Dampens T Regulatory Cell Function to Fuel Hepatic Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Sudrishti Chaudhary, Ravi Rai, Pabitra B Pal, Dana Tedesco, Daniel Rossmiller, Biki Gupta, Aatur D Singhi, Satdarshan P Monga, Arash Grakoui, Smita S Iyer and 1 more

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sudrishti ChaudharyPittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Ravi RaiPittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-2550-3811
Pabitra B PalPittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Dana TedescoEmory Vaccine Center, Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-8593-2066
Daniel RossmillerDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Biki GuptaPittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-2315-1026
Aatur D SinghiPittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Satdarshan P MongaPittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-8437-3378
Arash GrakouiEmory Vaccine Center, Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Smita S IyerDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Reben RaemanPittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3914-1797

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI RENGARAJAN, JYOTHI · 1985 to 2011
$114.0M
Protective immunity to HCV and rational vaccine designU19AI159819 · NIAID · EMORY UNIVERSITY · PI Arash Grakoui · 2021 to 2026
$16.6M
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLAUDETTE Marie ST CROIX · 2019 to 2026
$10.9M
Role of Wnt/Beta-Catenin Signaling in Liver DevelopmentR01DK062277 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2004 to 2026
$9.0M
Dynamics of antigen specific B and Tfh responses during acute and chronic HCVR01AI136533 · NIAID · EMORY UNIVERSITY · PI GRAKOUI, ARASH · 2018 to 2022
$3.8M
Mechanisms underlying hepatic immune cell recruitment in nonalcoholic fatty liver diseaseR01DK124351 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAEMAN, REBEN · 2021 to 2025
$2.1M
Human Liver Tissue & Hepatocytes Research Resource (HLTHRR)R24DK139775 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER, Satdarshan Singh Monga · 2024 to 2026
$1.4M
Targeting beta-catenin in liver pathology: Novel Interactions, Novel ParadigmsR01DK100287 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MONGA, SATDARSHAN SINGH · 2013 to 2016
$1.3M
Targeting CD4 T follicular helper cells for enhancing HIV vaccine induced humoral immunityR56AI150409 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA · 2021 to 2021
$774k
Role of CD4 T cells in the pathogenesis of non-alcoholic steatohepatitisK01DK110264 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAEMAN, REBEN · 2017 to 2021
$702k
NCRR NIH HHS P51 RR000165NIAID NIH HHS R01 AI136533NIAID NIH HHS R56 AI150409NIAID NIH HHS U19 AI159819NIDDK NIH HHS K01 DK110264NIDDK NIH HHS K01DK110264NIDDK NIH HHS P30 DK120531NIDDK NIH HHS P30DK120531NIDDK NIH HHS R01 DK062277NIDDK NIH HHS R01 DK100287NIDDK NIH HHS R01DK100287NIDDK NIH HHS R01 DK124351NIDDK NIH HHS R01DK124351NIDDK NIH HHS R01DK62277NIDDK NIH HHS R24 DK139775NIH HHS P51 OD011132NIH HHS P51OD011132NIH HHS R01AI136533NIH HHS R56AI150409NIH HHS RF1AG06001NIH HHS U19AI159819
6 · The paper itself

Abstract

The immunosuppressive T regulatory cells (Tregs) regulate immune responses and maintain immune homeostasis, yet their functions in metabolic dysfunction-associated steatotic liver disease (MASLD) remain controversial. Here we report increased accumulation of Tregs and effector T cells within the liver parenchyma of mice fed a Western diet (WD). This pattern was also observed in MASH patients, where an increase in intrahepatic Tregs was noted. In the absence of adaptive immune cells in

Indexed as

Fatty LiverInflammationNon-alcoholic Fatty Liver DiseaseT-Lymphocytes, RegulatoryAnimalsHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutfibrosisinflammationMASHMASLDT regulatory cells

Identifiers

PMID41597240
PMCPMC12839435

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.