Bovine Parainfluenza Virus Type 3 Infection Reprograms the Bovine Serum Lipidome Associated with Phosphatidylinositol Depletion and Sphingolipid Axis Activation.

Shubo Wen, Jiongjie Zhang, Na Lu, Deqing Tian, Lingpin Meng, Zheng Gao, Yang Song

Abstract read

In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Shubo WenCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.

Jiongjie ZhangCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID 0009-0006-0522-1525

Na LuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.

Deqing TianCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.

Lingpin MengCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.

Zheng GaoCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID 0009-0009-3731-5827

Yang SongCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.

Funding

National Natural Science Foundation of China No. 32260848the Innovation and Entrepreneurship Program for Returned Overseas Scholars in Inner Mongolia 2024LXCX002The Natural Science Foundation of Inner Mongolia No.2022LHQN03009, 2024MS03002Young Scientific and Technological Talents in Inner Mongolia No. NJYT23095, NJYT22053

6 · The paper itself

Abstract

Bovine Parainfluenza Virus Type 3 (BPIV3) is a critical pathogen in the Bovine Respiratory Disease Complex (BRDC), leading to significant economic losses in the cattle industry. However, the metabolic reprogramming induced by BPIV3 in cattle remains poorly understood. This study aimed to investigate the impact of BPIV3 infection on the serum metabolome of Simmental cattle using untargeted metabolomics and ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS). The results revealed significant alterations in the lipidome, including the upregulation of phosphatidylcholine (PC) and phosphatidylglycerol (PG), and the downregulation of phosphatidylinositol (PI). Sphingolipid metabolism also showed considerable changes, with increased levels of Trihexosylceramide and D-erythro-Sphingosine C-17. Furthermore, metabolic pathway analysis identified enriched pathways related to lipid metabolism, amino acid metabolism, and energy sensing. These findings suggest that BPIV3 infection induces substantial shifts in lipid metabolism, which may facilitate viral replication and immune evasion. Our results provide a deeper understanding of the metabolic changes in BPIV3-infected cattle and propose potential targets for therapeutic intervention.

Indexed as

BPIV3phosphatidylcholinephosphatidylinositol

Identifiers

PMID41597770

DOI10.3390/microorganisms14010252

PMCPMC12843776

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.