Evidence map›Paper›PMID 41597791›Full record

ArticleMicromachines2025

Magnetically Sculpted Microfluidics for Continuous-Flow Fractionation of Cell Populations by EpCAM Expression Level.

Zhenwei Liang, Xiaolei Guo, Xuanhe Zhang, Yiqing Chen, Chuan Du, Yuan Ma, Jiadao Wang

Abstract read
In one paragraph

Article in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhenwei LiangDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0009-0000-5995-1191
Xiaolei GuoDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-5088-2959
Xuanhe ZhangDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0009-0001-7490-1384
Yiqing ChenDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0009-0004-7123-0150
Chuan DuLenCyte Biotechnology (Xuzhou City) Co., Ltd., Xuzhou 221000, China.
Yuan MaDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-3595-2450
Jiadao WangDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-7801-9180

Funding

National Natural Science Foundation of China 52205312National Natural Science Foundation of China 52275200the Key Project of Innovation Fund of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation 23-NCRC-CXJJ-ZD1-4
6 · The paper itself

Abstract

Continuous-flow separation of magnetically labeled cells according to surface-marker expression levels is increasingly needed to study phenotypic heterogeneity and support downstream assays. Here, we present a microfluidic platform that uses spatially engineered soft magnetic strips (SMS) to sculpt lateral magnetic deflection fields for quantitative, label-guided cell fractionation. Under a uniform bias field, the SMS generates controllable magnetic gradients within the microchannel, producing distinct lateral velocities among EpCAM-labeled tumor cells that carry different Dynabead loads, which indirectly report membrane protein expression. Multi-outlet collection converts these "race-based" trajectory differences into discrete expression-level-resolved fractions. A COMSOL-MATLAB framework and a force-equivalent metric |(

Indexed as

continuous-flow fractionationEpCAM expression levelmagnetically sculpted microfluidicsmicrofluidic cell sorting

Identifiers

PMID41597791
PMCPMC12844116

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.