Evidence map›Paper›PMID 41598166›Full record

ReviewLife (Basel, Switzerland)2025

Cell Surface Markers of Mesenchymal Stem Cells: Current Knowledge and Advances in Characterization Technologies.

Angelo Santoro, Manuela Grimaldi, Carmen Marino, Enza Napolitano, Michela Buonocore, Anna Maria D'Ursi

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Differential Response of Stro-1Journal of functional biomaterials · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angelo SantoroDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Salerno, Italy.ORCID 0000-0002-9690-907X
Manuela GrimaldiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Salerno, Italy.ORCID 0000-0001-7354-8008
Carmen MarinoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Salerno, Italy.
Enza NapolitanoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Salerno, Italy.ORCID 0000-0001-8610-879X
Michela BuonocoreDepartment of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126 Naples, Italy.
Anna Maria D'UrsiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Salerno, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are pivotal in regenerative medicine due to their high differentiation potential and therapeutic versatility. MSCs are multipotent cells capable of differentiating into adipocytes, chondroblasts, osteoblasts, and, under specific conditions, neural, myocyte, and epidermal lineages. This cell type contributes to tissue repair, immunomodulation, and regenerative therapies for cardiac, orthopedic, and hematological disorders. Accurate identification and characterization of these stem cells are essential for both research and clinical applications. MSCs are typically defined by plastic adherence, expression of surface markers CD105, CD73, and CD90, low or absent expression of hematopoietic markers (CD45, CD34), and in vitro differentiation potential. Understanding the expression patterns and functional relevance of these surface markers is critical for improving isolation strategies, enhancing therapeutic efficacy, and minimizing adverse effects. This review provides a comprehensive overview of the principal surface markers of MSCs, highlighting their significance in stem cell biology and clinical translation.

Indexed as

mesenchymal stem cellsMSC heterogeneityphenotypic characterizationstromal subpopulationssurface marker profiling

Identifiers

PMID41598166
PMCPMC12842966

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.