Evidence mapPaperPMID 41598438Full record

ReviewJournal of clinical medicine2026

Investigating the Impact of Antioxidant Supplementation on Male Infertility: A Scoping Review.

Emmanouil Andreou, Charalampos Karachalios, Paraskevas Perros, Ilias Liapis, Georgia Koutsogeorgopoulou, Eftichia Katagi, Marios-Nektarios Filis, Alexandros Nakis, Vasileios Tzikoulis, Athanasios Chionis and 4 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emmanouil AndreouFaculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Charalampos KarachaliosFaculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-5258-4701
Paraskevas PerrosGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.ORCID 0009-0000-6454-7855
Ilias LiapisBirmingham Women's Hospital, Birmingham B15 2TG, West Midlands, UK.
Georgia KoutsogeorgopoulouFaculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0007-5499-3369
Eftichia KatagiGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.
Marios-Nektarios FilisGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.
Alexandros NakisGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.
Vasileios TzikoulisFaculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8265-1605
Athanasios ChionisGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.
Konstantinos DaglasGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.
Angeliki PapadimitriouGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.
Christos-Konstantinos MichalopoulosFaculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Antonios LagadasGynecology Clinic, General Hospital of Athens "LAIKO", 11527 Athens, Greece.ORCID 0009-0009-0615-3597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility affects thousands of couples internationally, leaving a profound effect on their families and communities. According to the World Health Organization (WHO), approximately one out of six individuals of reproductive age worldwide experiences infertility in their life span. Approximately 35% of infertile couples are affected by male factor infertility, in which semen analysis is the gold standard diagnostic procedure. Oxidative stress (OS) is considered to play a pivotal role in the pathogenesis of male infertility. A thorough literature search was conducted in PubMed/MEDLINE, Scopus and Google Scholar databases, using MeSH terms and free-text keywords, to retrieve eligible articles published in the last decade, focusing on the potential beneficial role of oral antioxidants in male infertility. Antioxidant supplementation appears to improve the majority of sperm parameters. Therefore, antioxidant therapy is emerging as a promising aid in addressing male infertility. The purpose of this comprehensive literature review is to evaluate the significance of antioxidant supplementation in improving sperm parameters. Most of the included randomized controlled trials demonstrated the positive effects of oral antioxidants in various parameters, such as sperm concentration, total sperm count, motility and progressive motility. Consequently, pregnancy outcomes were evaluated, and increased pregnancy rates were reported in the majority of the included studies.

Indexed as

antioxidantmale infertilityoxidative stresssemen analysissperm DNA oxidation

Identifiers

PMID41598438
PMCPMC12842426

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.