Evidence map›Paper›PMID 41599001›Full record

ArticlePathogens (Basel, Switzerland)2025

Trypanocidal Activity of Dual Redox-Active Quinones:

Raquel B Duarte, Victor F S Ramos, Juliana M C Barbosa, Gabriel M Oliveira, Emilay B T Diogo, Renata G Almeida, Alastair J J Lennox, Eufrânio N da Silva Júnior, Yasmin Pedra-Rezende, Rubem F S Menna-Barreto

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Phenotypic Analysis of the Anti-Molecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raquel B DuarteLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
Victor F S RamosLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
Juliana M C BarbosaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
Gabriel M OliveiraLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
Emilay B T DiogoInstituto de Ciências Exatas, Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-5469-8860
Renata G AlmeidaInstituto de Ciências Exatas, Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0003-2896-0487
Alastair J J LennoxSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, UK.ORCID 0000-0003-2019-7421
Eufrânio N da Silva JúniorInstituto de Ciências Exatas, Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0003-1281-5453
Yasmin Pedra-RezendeLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
Rubem F S Menna-BarretoLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-1352-0641

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease is caused by the protozoan

Indexed as

Anti-Inflammatory AgentsChagas DiseaseMitochondriaQuinonesTrypanocidal AgentsTrypanosoma cruziAnimalsMiceNaphthoquinonesNitroimidazolesOxidation-ReductionReactive Oxygen SpeciesAnti-Inflammatory AgentsbenzonidazoleNaphthoquinonesNitroimidazolesQuinonesReactive Oxygen SpeciesTrypanocidal Agentsanti-inflammatory activitychemotherapymitochondrionnaphthoquinonesTrypanosoma cruzi

Identifiers

PMID41599001
PMCPMC12845226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.