Time-Dependent Outcomes of Convalescent Plasma in Early COVID-19: A Single-Center Cohort with a Host-Pathogen Perspective.

Katarzyna Kalinowska, Patrycja Bociąga, Benita Wiatrak

Abstract read

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Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Katarzyna KalinowskaDepartment and Clinic of Pulmonology and Lung Cancer, Wroclaw Medical University, Grabiszynska 105 St., 53-439 Wroclaw, Poland.

Patrycja BociągaDepartment of Transfusion Immunology, Lower Silesian Center of Oncology, Pulmonology and Hematology, 53-439 Wroclaw, Poland.

Benita WiatrakDepartment of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.ORCID 0000-0002-1404-2274

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence on COVID-19 convalescent plasma (CCP) is mixed. We examined associations between CCP administration and in-hospital outcomes among patients hospitalized during early pandemic waves in Poland.

methodsWe conducted a retrospective, single-center cohort study of adults hospitalized with COVID-19 between October 2020 and January 2021. Patients receiving CCP were compared with contemporaneous controls without CCP. Primary outcomes were in-hospital mortality and discharge alive. Requirement for invasive mechanical ventilation/intubation was summarized descriptively because timing of intubation was not reliably available. Group comparisons used χ

resultsThe cohort included 224 patients (CCP,

conclusionsIn this early-wave retrospective cohort, CCP administration was associated with lower in-hospital mortality and higher discharge rates. Exploratory analyses adjusted for concomitant in-hospital therapies and severity markers should be interpreted as prognostic associations rather than evidence of causal efficacy.

Indexed as

COVID-19SARS-CoV-2AgedCOVID-19 SerotherapyFemaleHospital MortalityHost-Pathogen InteractionsHumansImmunization, PassiveMaleMiddle AgedPolandPrognosisRespiration, ArtificialRetrospective StudiesTreatment Outcomecompeting risksCOVID-19 convalescent plasmahost–pathogen interactionimmunosuppressionlandmark analysistime-varying exposure

Identifiers

PMID41599021

DOI10.3390/pathogens15010037

PMCPMC12844878

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