ArticlePathogens (Basel, Switzerland)2026
2-Aminothiophene Derivative SB-83 Inhibits Trypanothione Reductase and Modulates Cytokine Production in
Airton Lucas Sousa Dos Santos, Vanessa Maria Rodrigues de Souza, Julyanne Maria Saraiva de Sousa, Raiza Raianne Luz Rodrigues, Mércya Lopes Braga, Maria Gabrielly Gonçalves Da Silva Sousa, Douglas Soares de Oliveira, Mirely Vitória Farias da Silva, Edeildo Ferreira da Silva-Junior, Thaís Amanda de Lima Nunes and 6 more
Abstract read
In one paragraphArticle in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Airton Lucas Sousa Dos SantosInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.ORCID 0000-0003-1975-9570 Vanessa Maria Rodrigues de SouzaInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.
Julyanne Maria Saraiva de SousaInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.
Raiza Raianne Luz RodriguesInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.
Mércya Lopes BragaInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.
Maria Gabrielly Gonçalves Da Silva SousaInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.
Douglas Soares de OliveiraInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.
Mirely Vitória Farias da SilvaResearch Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, AC Simões Campus, Federal University of Alagoas, Maceió 57072-970, AL, Brazil.ORCID 0000-0002-3405-9794 Edeildo Ferreira da Silva-JuniorResearch Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, AC Simões Campus, Federal University of Alagoas, Maceió 57072-970, AL, Brazil.ORCID 0000-0002-1527-4501 Thaís Amanda de Lima NunesLaboratory of Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, MG, Brazil.ORCID 0000-0002-1924-4828 Marcos Vinícius da SilvaLaboratory of Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, MG, Brazil.ORCID 0000-0002-2966-7621 Ingrid Gracielle Martins da SilvaMicroscopy and Microanalysis Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.ORCID 0000-0001-7654-044X Karine Brenda Barros-CordeiroMicroscopy and Microanalysis Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.
Sônia Nair BáoMicroscopy and Microanalysis Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-9873-3098 Francisco Jaime Bezerra Mendonça JuniorLaboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, PB, Brazil.ORCID 0000-0003-3588-833X Klinger Antonio da Franca RodriguesInfectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Delta do Parnaíba, Parnaíba 64202-020, PI, Brazil.ORCID 0000-0003-3904-3529 Funding
National Council for Scientific and Technological Development 403260/2021-3
6 · The paper itselfAbstract
Chagas disease remains a significant neglected tropical disease that predominantly affects vulnerable populations in rural, low-income areas of Latin America. The management of this condition is severely hindered by the limitations of current therapies, which are characterized by substantial toxicity, diminished efficacy during the chronic phase, and the emergence of parasitic resistance. Given the promising activity of SB-83 (a 2-aminothiophenic derivative) against
Indexed as
CytokinesNADH, NADPH OxidoreductasesThiophenesTrypanocidal AgentsTrypanosoma cruziAnimalsChagas DiseaseChlorocebus aethiopsHumansReactive Oxygen SpeciesVero CellsCytokinesNADH, NADPH OxidoreductasesReactive Oxygen SpeciesThiophenesTrypanocidal Agentstrypanothione reductase2-aminothiopheneschagas diseaseelectron microscopyreactive oxygen speciesTrypanosoma cruzitrypanothione reductase inhibitor
Identifiers
PMID41599048
PMCPMC12845054
What Socratic holds
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