ArticlePathogens (Basel, Switzerland)2026
Helminth Antigens Modulate Virus-Induced Activation of CD154 (CD40L) Expression on T Cells in
Brice Armel Nembot Fogang, Kathrin Arndts, Tomabu Adjobimey, Michael Owusu, Vera Serwaa Opoku, Derrick Adu Mensah, John Boateng, Jubin Osei-Mensah, Julia Meyer, Ute Klarmann-Schulz and 6 more
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In one paragraphArticle in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
16 authors.
Brice Armel Nembot FogangDepartment of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.ORCID 0000-0002-3499-3659 Kathrin ArndtsInstiute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hosital Bonn, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0003-1091-4861 Tomabu AdjobimeyInstiute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hosital Bonn, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-4353-2897 Michael OwusuKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.ORCID 0000-0001-5066-150X Vera Serwaa OpokuKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.ORCID 0000-0001-7950-6650 Derrick Adu MensahDepartment of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.ORCID 0000-0002-8972-1757 John BoatengDepartment of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.ORCID 0000-0003-1309-2840 Jubin Osei-MensahKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.ORCID 0000-0003-3470-2994 Julia MeyerInstiute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hosital Bonn, University of Bonn, 53127 Bonn, Germany.
Ute Klarmann-SchulzInstiute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hosital Bonn, University of Bonn, 53127 Bonn, Germany.
Sacha HornInstitute of Infectious Diseases and Tropical Medicine, LMU University Hospital, 80802 Munich, Germany.ORCID 0000-0001-7965-5728 Inge KroidlInstitute of Infectious Diseases and Tropical Medicine, LMU University Hospital, 80802 Munich, Germany.ORCID 0000-0002-6949-346X Alexander Y DebrahKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.
Achim HoeraufInstiute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hosital Bonn, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-8671-3831 Manuel RitterInstiute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hosital Bonn, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0001-8667-2067 Linda B DebrahDepartment of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi PMB UPO, Ghana.
Funding
Bundesministerium für Forschung, Technologie und Raumfahrt 8120485European & Developing Countries Clinical Trials Partnership TMA2018SF-2451-ASTAWOLGerman Academic Exchange Service G-WAC
6 · The paper itselfAbstract
backgroundThe interaction between helminth and viral infections has important implications for understanding viral disease outcomes and vaccine efficacy in helminth-endemic regions. We previously demonstrated that helminth seropositivity is associated with reduced Th1/Th17 cytokine levels and reduced COVID-19 severity; however, the underlying immunological mechanisms remain unclear. This study further investigated these mechanisms by assessing how helminth antigens influence SARS-CoV-2-induced T-cell responses in individuals infected with filarial parasites
methodsPeripheral blood mononuclear cells (PBMCs) from 43 participants, including
resultsFluorescence-activated cell sorting analysis showed a significant reduction in SARS-CoV-2-induced CD154 expression on CD4
conclusionThese findings demonstrate that helminth antigens modulate functional SARS-CoV-2-induced T-cell responses, offering a potential mechanism through which helminth co-infections shape antiviral immunity, vaccine efficacy, and clinical disease outcomes.
Indexed as
Antigens, HelminthCD40 LigandCOVID-19Onchocerca volvulusOnchocerciasisSARS-CoV-2AdultAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansLymphocyte ActivationMaleMiddle AgedAntigens, HelminthCD40 LigandCD154 (CD40L)+ T cellCD4+ T cellCD8+ T cellco-infectionhelminthimmune modulationSARS-CoV-2virus
Identifiers
PMID41599077
PMCPMC12844669
What Socratic holds
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