Evidence map›Paper›PMID 41599273›Full record

ReviewMolecules (Basel, Switzerland)2026

Procyanidins: Structural Properties, Production Methods, and Modern Applications.

Aleksandr Yu Zakharov, Dmitriy Berillo, Annie Ng, Damir S Aidarkhanov, Anna V Tukesheva, Kamila M Temirkulova, Ainur Tanybayeva, Zulkhair A Mansurov, Mannix P Balanay, Vladimir V Pavlenko

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Hormetic Antioxidant Effects ofInternational journal of molecular sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aleksandr Yu ZakharovThe Institute of Combustion Problems, St. Bogenbai Batyr, 172, Almaty 0500012, Kazakhstan.
Dmitriy BerilloInternational Campus, M. Kozybayev North-Kazakhstan University, Pushkin Street, 86, Petropavlovsk 150000, Kazakhstan.ORCID 0000-0003-2534-9367
Annie NgNazarbayev University Research Administration, Kabanbay Batyr Ave., 53, Astana 010000, Kazakhstan.ORCID 0000-0002-5975-2499
Damir S AidarkhanovNazarbayev University Research Administration, Kabanbay Batyr Ave., 53, Astana 010000, Kazakhstan.ORCID 0000-0002-8074-3829
Anna V TukeshevaThe Institute of Combustion Problems, St. Bogenbai Batyr, 172, Almaty 0500012, Kazakhstan.
Kamila M TemirkulovaThe Institute of Combustion Problems, St. Bogenbai Batyr, 172, Almaty 0500012, Kazakhstan.
Ainur TanybayevaDepartment of Geography and Environmental Sciences, Al-Farabi Kazakh National University, al-Farabi Ave., 71, Almaty 050040, Kazakhstan.
Zulkhair A MansurovThe Institute of Combustion Problems, St. Bogenbai Batyr, 172, Almaty 0500012, Kazakhstan.
Mannix P BalanayDepartment of Chemistry, Nazarbayev University, Kabanbay Batyr Ave., 53, Astana 010000, Kazakhstan.ORCID 0000-0003-2479-8582
Vladimir V PavlenkoThe Institute of Combustion Problems, St. Bogenbai Batyr, 172, Almaty 0500012, Kazakhstan.

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan AP22786994Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan BR28713323
6 · The paper itself

Abstract

Procyanidins, a class of substances widely distributed in nature, have attracted the attention of the scientific community due to their bioactive properties, especially with regard to human health. This review is based on an extensive examination of peer-reviewed literature, patents, and clinical trial reports published between 2005 and 2025. From an initial pool of more than 300 documents, 283 studies were selected according to criteria of scientific rigor, methodological clarity, and relevance to the research objectives. A literature search was performed using PubMed, PubChem, Google Scholar, Scopus and ResearchGate employing keywords such as Procyanidins, chemical structure, extraction, and health effects. This article provides a comprehensive overview of current methods for obtaining these compounds, which include both natural sources and synthetic approaches. It provides a concise summary of the molecular structure of procyanidins and emphasizes the importance of understanding their conformational features for predicting biological activity. The challenges of establishing correlations between the structural features of procyanidins and their properties are described. In addition, this article explores the many potential applications of these compounds, spanning both biochemistry and the field of design and synthesis of novel materials. This review provides a comprehensive evaluation of Procyanidins, focusing on their geometrical conformation analysis through advanced NMR spectroscopy techniques including homonuclear correlation (COSY, TOCSY), heteronuclear one-bond (HSQC, HMQC), multiple-bond (HMBC) experiments, and through-space correlation (NOESY) in conjunction with various extraction methodologies.

Indexed as

BiflavonoidsCatechinProanthocyanidinsHumansMolecular StructureBiflavonoidsCatechinProanthocyanidinsextraction methodsprocyanidinsprocyanidins conformationsreviewsynthetic methods

Identifiers

PMID41599273
PMCPMC12843634

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.