ReviewMolecules (Basel, Switzerland)2026
Mulberry Leaf-Derived Bioactive Constituents on Diabetes: Structure, Extraction, Quality Analysis, and Hypoglycemic Mechanisms.
Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
(1) Background: Diabetes mellitus is a chronic metabolic disease with a rising global prevalence. Mulberry leaf (ML), a traditional medicinal and edible plant, possesses notable hypoglycemic effects and has a long history of usage. This review aims to systematically consolidate the research progress on the hypoglycemic constituents derived from ML, including their chemical structure, extraction methods, quality analysis techniques, and hypoglycemic mechanisms. (2) Methods: Adhering to the Preferred Reporting Items for Systematic Reviews (PRISMA 2020) guidelines, a comprehensive literature search was conducted using Web of Science and PubMed databases to find relevant studies published between 2015 and 2025. (3) Results: This review evaluates both conventional and modern techniques such as water extraction, ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and enzyme-assisted extraction (EAE), highlighting their advantages and limitations when applied on ML. Additionally, this review examines the analytical techniques applied in the quality control of ML and its constituents. This is complemented by a summary of hypoglycemic mechanisms, focusing on the inhibition of oxidative stress, amelioration of insulin resistance, regulation of related enzyme activity, and modulation of gut microbiota. (4) Conclusions: ML demonstrates considerable potential for treating diabetes. However, further studies are needed for new drug discovery based on new ML-derived bioactive constituents, highly efficient extraction methods, quality analysis techniques, and underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.