Evidence map›Paper›PMID 41599424›Full record

ArticleMolecules (Basel, Switzerland)2026

Nitroxide Hormesis in Yeast: 4-Hydroxy-TEMPO Modulates Aging, and Cell Cycle.

Mateusz Mołoń, Patrycja Kielar, Eliza Molestak, Agnieszka Mołoń, Ewelina Kuna, Marek Biesiadecki, Przemysław Grela, Alan González-Ibarra, Sabina Galiniak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mateusz MołońFaculty of Biology, Natural Protection, and Sustainable Development, University of Rzeszow, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.ORCID 0000-0002-9962-6788
Patrycja KielarFaculty of Medicine, University of Rzeszów, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.
Eliza MolestakDepartment of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland.ORCID 0000-0002-6595-7351
Agnieszka MołońFaculty of Medicine, University of Rzeszów, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.
Ewelina KunaFaculty of Biology, Natural Protection, and Sustainable Development, University of Rzeszow, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.ORCID 0000-0002-3203-3195
Marek BiesiadeckiFaculty of Medicine, University of Rzeszów, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.
Przemysław GrelaDepartment of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland.
Alan González-IbarraDepartment of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland.
Sabina GaliniakFaculty of Medicine, University of Rzeszów, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.ORCID 0000-0002-1129-3553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

4-hydroxy-TEMPO is a water-soluble nitroxide radical with potent antioxidant and redox-modulating properties. Its small molecular weight and membrane permeability enable it to act as a superoxide dismutase mimetic, efficiently scavenging reactive oxygen species and mitigating oxidative damage. In this study, we investigated the physiological and transcriptomic effects of 4-hydroxy-TEMPO in

Indexed as

Cell CycleCyclic N-OxidesNitrogen OxidesSaccharomyces cerevisiaeAntioxidantsGene Expression Regulation, FungalHydroxylamineOxidation-ReductionOxidative StressSaccharomyces cerevisiae ProteinsAntioxidantsCyclic N-OxidesHydroxylamineNitrogen OxidesSaccharomyces cerevisiae ProteinsTEMPOL-H4-hydroxy-TEMPOagingcell cycleribosomeRNA-Seqyeast

Identifiers

PMID41599424
PMCPMC12843841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.