ReviewPharmaceuticals (Basel, Switzerland)2026
Cinobufagin as a Potential Intervention Against Liver Cancer-A Comprehensive Review.
Nicole Simone de Lima Coelho, Victória Dogani Rodrigues, Otávio Simões Girotto, Renato César Moretti Júnior, Vítor Engrácia Valenti, Maria Angélica Miglino, Mônica Duarte da Silva, Caio Sérgio Galina Spilla, Ana Luiza Decanini Miranda de Souza, Sandra Maria Barbalho and 1 more
Abstract readReview
In one paragraphReview in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Nicole Simone de Lima CoelhoDepartment of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília 17519-030, SP, Brazil.ORCID 0009-0000-5990-5849 Victória Dogani RodriguesDepartment of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília 17519-030, SP, Brazil.
Otávio Simões GirottoDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.ORCID 0000-0003-0518-0795 Renato César Moretti JúniorDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.
Vítor Engrácia ValentiSystematic Reviews and Meta-Analyses Center, School of Philosophy and Sciences, São Paulo State University, Marília 17525-900, SP, Brazil.ORCID 0000-0001-7477-3805 Maria Angélica MiglinoGraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.ORCID 0000-0003-4979-115X Mônica Duarte da SilvaGraduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (FMVZ/USP), São Paulo 05508-270, SP, Brazil.
Caio Sérgio Galina SpillaDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.
Ana Luiza Decanini Miranda de SouzaDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.
Sandra Maria BarbalhoDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.ORCID 0000-0002-5035-876X Lucas Fornari LaurindoDivision of Cellular Growth, Hemodynamic, and Homeostasis Disorders, Graduate Program in Medical Sciences, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo 01246-903, SP, Brazil.ORCID 0000-0003-3159-0982 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Liver cancer remains a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form. Despite advancements in treatment, high recurrence rates and the limited efficacy of conventional therapies highlight the need for novel interventions. Cinobufagin (CB), a bufadienolide extracted from the parotid secretion of
Indexed as
apoptosisbufadienolidecinobufaginhepatocellular carcinomaliver cancermalignancymigration
Identifiers
PMID41599754
PMCPMC12845374
What Socratic holds
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