Evidence map›Paper›PMID 41599795›Full record

ReviewNutrients2026

Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines.

Ploutarchos Pastras, Ioanna Aggeletopoulou, Maria Bali, Christos Triantos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ploutarchos PastrasDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0009-0001-7790-7845
Ioanna AggeletopoulouDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-4489-1485
Maria BaliDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.
Christos TriantosDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-3094-8209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable Bowel Syndrome (IBS) affects 4-15% of the global population, and the limited efficacy of existing pharmacologic therapies has driven growing interest in plant-based therapeutic options among both patients and clinicians. A comprehensive assessment of all plant extracts investigated in IBS is therefore essential, given the limited effectiveness of conventional treatments and the increasing interest in complementary approaches. Evidence from recent systematic reviews and meta-analyses consistently indicates that peppermint oil is the most effective botanical agent, particularly for reducing abdominal pain and overall IBS symptom severity. Iberogast (STW-5 and STW-5 II) has also demonstrated clinical improvements across multiple trials, while curcumin shows mechanistic and preliminary clinical potential by modulating several IBS-related pathways. In contrast, extracts such as

Indexed as

Irritable Bowel SyndromePhytotherapyPlant ExtractsHumansMentha piperitaPlant OilsPractice Guidelines as TopicTreatment Outcomepeppermint oilPlant ExtractsPlant Oilsherbal medicineinternational guidelinesIrritable Bowel Syndromemechanisms of actionpeppermint oilplant extractstreatment

Identifiers

PMID41599795
PMCPMC12845297

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.