Evidence map›Paper›PMID 41599799›Full record

ArticleNutrients2026

Plasma Phospholipid Biomarkers Related to the Risk of Cognitive Decline in the Elderly: Results from a Cohort Study.

Ting-Ting Liu, Jia-Wei Xie, Xin Long, Xin-Can Yu, Shan-Shan Jia, Qing-Qing Man, Jing Li, Pu-Jun Quan, Ke-Chang Shan, Jian Zhang and 2 more

Abstract read
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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Ting-Ting LiuNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Jia-Wei XieNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Xin LongDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Xin-Can YuDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Shan-Shan JiaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Qing-Qing ManNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Jing LiDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
Pu-Jun QuanDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Ke-Chang ShanDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Jian ZhangNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Shuang SongNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.ORCID 0000-0003-3000-1912
Dan LiuDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.

Funding

Construction of High-level University of Guangdong G624330422Construction of High-level University of Guangdong G625330219National Natural Science Foundation of China 81372991National Natural Science Foundation of China 82003443National Natural Science Foundation of China 82204044Young Scholar Science Foundation of China CDC 2022A203
6 · The paper itself

Abstract

Phospholipids provide both structural and functional varieties for neuro cells, and their dysregulation in brain has been related to pathogenesis of cognitive impairment. The reflection of these phospholipid alterations in the blood might serve as biomarkers for the early recognition of cognitive decline risk preceding clinical symptoms and provide potential targets for intervention. In this cohort study, detailed phospholipid molecular profiles including 229 species were quantified. A total of 209 participants aged 60-80 years (including 138 women and 73 men) were followed for one year, during which 32 participants developed significant cognitive decline, defined as a decrease of three or more points in the Montreal Cognitive Assessment score. A biomarker panel of eight phospholipid molecular species related to cognitive decline was identified by Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression between cases and non-cases. Among these, four biomarkers, including PE(O-40:5), LPC(18:3), PI(38:2) and PA(39:4), were further proved to be significantly associated with the risk of cognitive decline through a logistic regression model, indicating that the degradation of phospholipids and the accumulation of ether phospholipid and PI might participate in the process of cognitive decline in early stage. By adding the eight phospholipid biomarkers to a reference model that included demographics, lifestyle, hypertension, fasting blood glucose and blood lipid parameters, the AUC value of the predictive model improved from 0.743 to 0.866, which provided a possible auxiliary screening tool for the early detection of cognitive impairment in the elderly.

Indexed as

Cognitive DysfunctionPhospholipidsAgedAged, 80 and overBiomarkersCohort StudiesFemaleHumansLogistic ModelsMaleMiddle AgedRisk FactorsBiomarkersPhospholipidsbiomarkercognitive decline riskcohort studyphospholipid

Identifiers

PMID41599799
PMCPMC12844940

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.