Evidence map›Paper›PMID 41599800›Full record

Observational studyNutrients2026

Longitudinal Interaction Between Individualized Gut Microbial Dynamics and Diet Is Associated with Metabolic Health in School-Aged Children.

Changcan Feng, Mingyue Yang, Zhongmin Yang, Xin Liao, Shanshan Jiang, Lingling Li, Haiyan Lin, Yujing Sun, Zehua Wei, Zhongming Weng and 10 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Changcan FengSchool of Public Health, Xiamen University, Xiamen 361005, China.ORCID 0009-0000-1640-1579
Mingyue YangSchool of Public Health, Xiamen University, Xiamen 361005, China.ORCID 0009-0007-5400-9878
Zhongmin YangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Xin LiaoCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Shanshan JiangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Lingling LiSchool of Public Health, Xiamen University, Xiamen 361005, China.
Haiyan LinSchool of Public Health, Xiamen University, Xiamen 361005, China.
Yujing SunCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Zehua WeiSchool of Public Health, Xiamen University, Xiamen 361005, China.
Zhongming WengCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.ORCID 0000-0002-9346-532X
Daren WuCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Lingyu ZhangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.ORCID 0000-0002-4501-8445
Eytan WineDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada.
Karen L MadsenDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB T6G 1C9, Canada.ORCID 0000-0002-8636-0714
Edward C DeehanDepartment of Food Science and Technology, University of Nebraska, Lincoln, NE 68588-0235, USA.ORCID 0000-0001-7697-1418
Jian LiCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.ORCID 0000-0002-3444-3788
Jun ZengCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.ORCID 0000-0003-2103-4536
Jingwen LiuCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Zhengxiao ZhangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.ORCID 0000-0002-6977-4309
Chenxi CaiSchool of Public Health, Xiamen University, Xiamen 361005, China.ORCID 0009-0008-9318-1707

Funding

Fundamental Research Funds for the Central Universities 20720250178National Natural Science Foundation of China 32572585Natural Science Foundation of Fujian Province 2022J01332Natural Science Foundation of Xiamen, China 3502Z202573030
6 · The paper itself

Abstract

BACKGROUND/

objectivesChildhood metabolic dysregulation exerts a profound influence on the development of obesity and metabolic diseases. The human gut microbiota, with highly personalized characteristics, plays an important role in host metabolism. However, the dynamics of gut microbial features during this developmental phase are still unclear. This longitudinal observational study collected 204 fecal samples and 153 blood samples from 51 children (aged 8.90 ± 0.78 years) at four timepoints over 52 weeks, aiming to identify dynamic changes in individual gut microbiota and underlying mechanistic interactions that predict measures of pediatric metabolic health.

methodsFecal samples were subjected to 16S rRNA gene amplicon sequencing and short-chain fatty acid quantification. Serum samples were analyzed for biochemical tests. Dietary intake, physical activity, clinical phenotypes, early-life factors, and fecal characteristics were further assessed.

resultsIn the results, the fecal microbiota dynamics exhibit inter-individual variation among children, allowing classification into high- and low-stability subgroups based on intra-individual β-diversity variability. Children with low-stability microbiota had adverse blood lipid profiles (

conclusionsThese findings suggested that the variation in the gut microbiota dynamics could be considered as a possible complementary biomarker to understand the individualized responses within dietary interventions aimed at improving metabolic health in childhood. Further well-designed intervention study is needed to define these observational associations.

Indexed as

DietGastrointestinal MicrobiomeChildFatty Acids, VolatileFecesFemaleHumansLongitudinal StudiesMaleRNA, Ribosomal, 16SFatty Acids, VolatileRNA, Ribosomal, 16Sgut microbiotaindividual variabilityobesity-related biomarkersschool-aged childrentemporal dynamics

Identifiers

PMID41599800
PMCPMC12845436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.