Evidence map›Paper›PMID 41599846›Full record

ReviewNutrients2026

Best Practices for the Nutritional Management of Infantile-Onset Lysosomal Acid Lipase Deficiency: A Case-Based Discussion.

Fiona J White, Javier de Las Heras, Celia Rodríguez-Borjabad, Simon A Jones, Alexander Y Kim, Jenna Moore, Florian Abel, Laura Frank, Rosie Jones, Suresh Vijay

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fiona J WhiteGenomic Medicine, St. Mary's Hospital, MFT, University of Manchester, Manchester M13 9WL, UK.ORCID 0000-0003-4936-1029
Javier de Las HerasBiobizkaia Health Research Institute, 48903 Barakaldo, Spain.ORCID 0000-0001-5663-537X
Celia Rodríguez-BorjabadUnitat de Nutrició i Unitat de Medicina Vascular i Metabolisme, Hospital Sant Joan de Reus, 43204 Reus, Spain.ORCID 0000-0001-8160-3716
Simon A JonesGenomic Medicine, St. Mary's Hospital, MFT, University of Manchester, Manchester M13 9WL, UK.ORCID 0000-0002-5117-0566
Alexander Y KimDivision of Genetics, Department of Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, FL 33701, USA.ORCID 0000-0002-2814-2612
Jenna MooreNutritional Services, Johns Hopkins All Children's Hospital, St. Petersburg, FL 33701, USA.
Florian AbelDepartment of Global Medical Affairs, Alexion, AstraZeneca Rare Disease, Boston, MA 02210, USA.
Laura FrankDepartment of Metabolics, Alexion, AstraZeneca Rare Disease, Boston, MA 02210, USA.
Rosie JonesDietetics Department, Birmingham Women's and Children's Hospitals NHS Foundation Trust, Birmingham B15 2TG, UK.ORCID 0000-0003-2683-4807
Suresh VijayUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, UK.

Funding

Alexion, AstraZeneca Rare Disease N/A
6 · The paper itself

Abstract

Infantile-onset lysosomal acid lipase deficiency (LAL-D) (Wolman disease, historically) is a rare inherited, rapidly progressive disorder caused by pathogenic variants in the

Indexed as

Wolman DiseaseEnzyme Replacement TherapyFemaleHumansInfantMaleSterol EsteraseSebelipase alfaSterol Esterasedietary substrate reductionearly diagnosisearly treatmentenzyme replacement therapyinfantile-onset lysosomal acid lipase deficiencyLAL-Dmalabsorptionminimal lipid intakesebelipase alfasubstrate reduction therapyWolman disease

Identifiers

PMID41599846
PMCPMC12845284

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.