Evidence mapPaperPMID 41599903Full record

ArticleNutrients2026

Safranal-Standardized Saffron Extract Improves Metabolic, Cognitive, and Anxiolytic Outcomes in Aged Mice via Hypothalamic-Amygdalar Peptide Modulation.

Juan A Navarro, Ana Gavito, Sonia Rivas, Alonso Rodríguez-Martín, Elena Baixeras, Juan Decara, Pedro J Serrano-Castro, Yolanda Alfonso, Carlos Sanjuan, Antonia Serrano and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Frontiers in molecular neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juan A NavarroGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.ORCID 0000-0003-3089-0983
Ana GavitoGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.
Sonia RivasGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.
Alonso Rodríguez-MartínGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.
Elena BaixerasDepartamento de Bioquímica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Málaga, 29010 Málaga, Spain.ORCID 0000-0001-6955-2434
Juan DecaraGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.ORCID 0000-0002-9868-015X
Pedro J Serrano-CastroUnidad Clínica de Neurología, Hospital Regional Universitario, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.ORCID 0000-0002-3414-2707
Yolanda AlfonsoEuronutra S.L., Calle Johannes Kepler, 3, 29590 Málaga, Spain.
Carlos SanjuanEuronutra S.L., Calle Johannes Kepler, 3, 29590 Málaga, Spain.ORCID 0000-0003-3505-0481
Antonia SerranoGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.ORCID 0000-0002-8017-9754
Fernando Rodríguez de FonsecaGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain.ORCID 0000-0002-4516-5795

Funding

Consejería de Salud y Consumo - Junta de Andalucía HOR-2025-05Consejería de Universidad, Investigación e Innovación - Junta de Andalucía PI21/00291Instituto de Salud Carlos III (ISCIII) and European Union PI25/02036 and "Programa Fortalece" (FORT23/00013)Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación RTC2019-007329-1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingAmygdalaAnti-Anxiety AgentsAnxietyCognitionCrocusCyclohexenesHypothalamusPlant ExtractsTerpenesAnimalsBehavior, AnimalLipid MetabolismMaleMiceMice, Inbred C57BLAnti-Anxiety AgentsCyclohexenesNeuropeptidesPlant ExtractssafranalTerpenesaginganxietyappetitebraincognitive impairmentcrocinsdementialipid metabolismmicesaffronsafranal

Identifiers

PMID41599903
PMCPMC12845050

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.