Evidence mapPaperPMID 41601469Full record

ArticleFrontiers in health services2025

Demonstrating the value for money of implementing evidence-based treatment: the case for further investment in magnesium sulphate as a neuroprotectant for preterm births.

Carlos Sillero-Rejon, Hannah B Edwards, William Hollingworth, Brent C Opmeer, Christalla Pithara-McKeown, Frank de Vocht, Sabi Redwood, David Odd, Karen Luyt, Hugh McLeod

Abstract read
In one paragraph

Article in Frontiers in health services, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. International disparities in use of antenatal magnesium sulfate and antenatal steroids for the preterm baby.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlos Sillero-RejonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Hannah B EdwardsPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
William HollingworthPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Brent C OpmeerNational Institute for Health and Care Research Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom.
Christalla Pithara-McKeownPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Frank de VochtPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Sabi RedwoodPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
David OddPopulation Medicine, Cardiff University, Cardiff, United Kingdom.
Karen LuytPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Hugh McLeodPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Effective and cost-effective treatments are not always optimally implemented. The benefit forgone due to sub-optimal implementation is often not considered or estimated. We use the economic concept of "incremental net monetary benefit" (INMB) to demonstrate how this can be valued. This approach can inform decision-making when used to estimate the value for money of potential future quality improvement (QI) programmes. We illustrate these analyses using the case of antenatal magnesium sulphate (MgSO Methods: We estimated MgSO Results: The optimal uptake of MgSO Conclusions: The case of MgSO

Indexed as

cerebral palsycost-effectivenessimplementationneurodisabilitiesquality improvementvalue of implementation

Identifiers

PMID41601469
PMCPMC12833438

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.