ReviewFrontiers in psychiatry2025
Cardiovascular disease and depression: a bidirectional relationship and its clinical implications.
Review in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurotrophin System Alterations Associated with Neurotoxicity Accompanied by Carotid Artery Diseases-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Mental health symptoms following a pregnancy complicated by cardiovascular disease: scoping review.BJPsych open · 2026Review
- Blood ATX(N) Biomarkers and Cognitive Dysfunction in Severe Mental Illnesses.International journal of molecular sciences · 2026Review
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is strong evidence that depression is linked to greater rates of morbidity and death in people with cardiovascular disease (CVD), supporting its status as a key risk factor for the condition. Recent researches suggest a reciprocal relationship, with CVD potentially predisposing people to depressive disorders. Notably, depression has a high comorbidity rate with major cardiovascular disorders such as coronary artery disease and myocardial infarction, which may have a severe impact on patients' long-term outcomes. Several pathways, including neuroendocrine dysregulation, activation of the inflammatory system, and behavioral alterations, appear to underlie the connection between depression and CVD. On the other hand, CVD may lead to the pathophysiology of depression by altering brain hemodynamics and causing blood-brain barrier (BBB) damage. Current therapeutic approaches stress a multimodal approach that combines drug interventions, cognitive behavioral therapy, and lifestyle changes to improve patient results. This review summarizes the latest research findings on the complex connection between depression and cardiovascular diseases, as well as contemporary treatment options and clinical consequences.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.