ReviewFrontiers in neuroscience2025
Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Isolationof PASN from Argentine Squid Carcass By-Products Enhances Proliferation and Repair of hACs and PC12 In Vitro via Antioxidant Activity.Foods (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insomnia is a common clinical manifestation of central nervous system (CNS) dysfunction that may be attributable to the involvement of abnormalities in multiple systems. Dysfunction of the gamma-aminobutyric acid (GABA) system is one of the key pathologic factors responsible for the increased neural excitability. GABA has been regarded as the major inhibitory neurotransmitter in the CNS, which can maintain the dynamic balance of neural networks by regulating neuronal excitability. Traditional Chinese medicine (TCM), with its multi-component, multi-target therapeutic advantages, shows unique potential in regulating the GABAergic system to improve sleep disorders. Accordingly, this review systematically elucidated the underlying mechanisms of TCM in treating insomnia by regulating the GABAergic system. According to the results, the intervention pathways of TCM exhibited multidimensional characteristics. TCM could effectively enhance GABA levels, strengthen GABAergic neural signal transmission, and improve insomnia symptoms by activating GABA receptor expression, upregulating glutamic acid decarboxylase (GAD) expression, and inhibiting GABA transaminase (GABA-T) activity. Furthermore, TCM could regulate the function of the hypothalamic-pituitary-adrenal (HPA) axis, inhibit neuroinflammation, regulate circadian rhythms, and enhance neurotrophic mechanisms, thereby synergizing with the GABAergic system to exert a sedative and sleep-promoting effect. With a systematic elaboration of the mechanisms of the GABAergic system, findings in this study may provide a theoretical basis for establishing a TCM evaluation system for insomnia based on the modulation of the GABAergic system. It can also offer fresh insights into the diagnosis and treatment of insomnia from the perspective of TCM, expand new directions for clinical research, and supply potential reference for future in-depth studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.