Evidence map›Paper›PMID 41601561›Full record

ArticleIBRO neuroscience reports2025

Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage.

Nicolas Eden, Marius Marc-Daniel Mader, Jan Bremer, Jennifer Sauvigny, Jörn Grensemann, Marlene Fischer, Nils Schweingruber, Jens Gempt, Patrick Czorlich

Abstract read
In one paragraph

Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicolas EdenDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Marius Marc-Daniel MaderDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Jan BremerDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Jennifer SauvignyDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Jörn GrensemannDepartment of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Marlene FischerDepartment of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Nils SchweingruberDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Jens GemptDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Patrick CzorlichDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH). Methods: Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to Results: A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p < 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2-0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: -0.2-0.0 %; p = 0.043) 0.3 % (95 % CI: -0.6 % to -0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p < 0.001). Conclusions: Our pilot study shows only a very small effect of classical music such as Mozart's Symphony No. 40 in G

Indexed as

classical musicMozartphysiological effectssubarachnoid hemorrhagevasospasm

Identifiers

PMID41601561
PMCPMC12834021

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.