ArticleIBRO neuroscience reports2025
Relationship between COVID-19 and hypopituitarism: A two-sample Mendelian randomization study.
Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objectives: COVID-19 has been identified as causing damage to the nervous and endocrine systems, with observed effects on hypopituitarism. However, the effects of COVID-19 on hypopituitarism are controversial. In this study, we conducted MR analysis to investigate the relationship between COVID-19 and hypopituitarism. Study design: The MR study utilized publicly available summary statistics from an independent European cohort. Data were sourced from the EBI database for COVID-19(case N = 8316 and control N = 1549,095) and from the FinnGen database for hypopituitarism (case N = 910 and control N = 211,123). Independent genetic variants significantly associated with each exposure(P < 5 ×10-8) were considered as instrumental variables. The MR analysis and colocalisation analysis were underwent. Methods: Four methods were employed: IVW, MR-Egger regression, weighted median and weighted mode with sensitivity analyses conducted. Finally, colocalisation analysis was also conducted. Results: MR study analyses were performed using the IVW fixation method, and we found a significant causal association between COVID-19 and hypopituitarism. IVW OR= 1.283, 95 %CI(1.017, 1.617), p = 0.035; MR-Egger OR= 1.355, 95 % CI(0.850, 2.160), p = 0.291; OR= 1.327, 95 %CI(1.017, 1.732), p = 0.037 in the weighted median approach and OR= 1.330, 95 % CI(0.993, 1.782), p = 0.128 in the weighted modal approach, with the results of the sensitivity analysis showing a stable and suggestive of a causality that COVID-19 increases the risk of developing hypopituitarism. The probability of colocalization of COVID-19 and hypopituitarism was PP.H4.abf= 9.55 %. Conclusion: In this study, we have established a causal relationship between COVID-19 and the risk of hypopituitarism. This suggests that vigilance against the development of hypopituitarism is warranted following SARS-CoV-2 infection, and underscores the potential for long-term autonomic dysfunction in post-COVID-19 clinical management.
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