ArticleFrontiers in immunology2025
Efficacy of
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Aim: To investigate the therapeutic and preventive effects of the probiotic Methods: The experiment comprised five groups: Control group, Model group, PA53 prevention group, PA53 treatment group, and curcumin group. NAFLD was induced by feeding mice a high-fat diet (HFD), with body weight recorded weekly. At the end of the experiment, serum, liver, and ileum samples were collected from the mice. The levels of serum inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and interferon-inducible protein-10 (IP-10), as well as related blood biochemical markers such as alanine aminotransferase (ALT), glucose (GLU), triglyceride (TG), cholesterol (CHO), and low-density lipoprotein cholesterol (LDL-C), were measured. Hepatic lipid deposition was evaluated using hematoxylin and eosin (H&E) staining and oil red O staining. Additionally, fecal samples were collected at multiple time points and subjected to 16sRNA sequencing to assess changes in the gut microbiota. Results: PA53 significantly attenuated body weight gain, liver lipid accumulation, serum inflammatory cytokine levels while normalizing gut microbiota composition in mice, bringing these parameters closer to those of the control group. Compared to curcumin, PA53 proved more effective in controlling body weight gain and reducing liver fat accumulation. Furthermore, the preventive regimen yielded better outcomes than the therapeutic effect. While PA53 was less effective than curcumin in modulating certain immune responses and reducing specific cytokines (such as IL-6, IL-1β, TNF-α and IP-10), it still exerted significant anti-inflammation effects. Conclusion: In conclusion, PA53 demonstrates potential efficacy in mitigating HFD-induced NAFLD in mice, with its preventive effect appearing comparatively more prominent. Notably, PA53 exhibited superior performance over curcumin in key metabolic endpoints, which furnishes novel empirical evidence for its putative role in NAFLD management and augments the current body of knowledge regarding probiotic-based therapeutic strategies for metabolic liver diseases.
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