Evidence map›Paper›PMID 41601693›Full record

ReviewFrontiers in immunology2025

The TCR and LCK: foundations for T-cell activation and therapeutic innovation.

Nadine M Woessner, Valeria Uleri, Ondrej Stepanek, Susana Minguet

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nadine M WoessnerSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Valeria UleriLaboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Ondrej StepanekLaboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Susana MinguetSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The T cell receptor (TCR)-CD3 complex is crucial to adaptive immunity, driving antigen recognition and intracellular signaling cascades. CD3 subunits harbor key cytoplasmic motifs that recruit signaling proteins like LCK. While distal αβ TCR signaling is well-understood, gaps persist in our understanding of proximal signaling, particularly the roles of free

Indexed as

Lymphocyte ActivationLymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-CellT-LymphocytesAnimalsHumansImmunotherapy, AdoptiveReceptors, Antigen, T-Cell, gamma-deltaReceptors, Chimeric AntigenSignal TransductionLCK protein, humanLymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaReceptors, Chimeric AntigenimmunotherapyLcksignalingT cellsTCR - T cell receptor

Identifiers

PMID41601693
PMCPMC12832860

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.