Evidence map›Paper›PMID 41601701›Full record

ReviewFrontiers in immunology2025

T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform.

Sophie Tourdot, Anette Christine Karle, Marc Rosenbaum, Chloé Ackaert, Pauline Le Vu, Michael Gutknecht, Maryam Ahmadi, Annelies W Turksma, Timothy P Hickling

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophie TourdotPfizer Inc., Research and Development, Immunogenicity Sciences, Andover, MA, United States.
Anette Christine KarleNovartis Pharma AG, Biomedical Research Center, Immunogenicity and Mechanistic Immunology, Basel, Switzerland.
Marc RosenbaumHexal AG (a Sandoz Company), Global Clinical Development, Clinical Bioanalytics, Holzkirchen, Germany.
Chloé AckaertIQVIA Laboratories, In vitro Immunology (ImmunXperts SA), Gosselies, Belgium.
Pauline Le VuAbzena Ltd., Bioassay Department, Cambridge, United Kingdom.
Michael GutknechtNovartis Pharma AG, Biomedical Research Center, Immunogenicity and Mechanistic Immunology, Basel, Switzerland.
Maryam AhmadiAbzena Ltd., Bioassay Department, Cambridge, United Kingdom.
Annelies W TurksmaImmunotherapy Center Amsterdam University Medical Centers (UMC), Amsterdam, Netherlands.
Timothy P HicklingRoche Pharma Early Research and Development, Cambridge, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CD4-Positive T-LymphocytesT-LymphocytesAnimalsEuropeHumansLymphocyte ActivationRisk Assessmentbest practicesde-immunizationimmunogenicitymitigationnon-clinical risk assessmentT cell assays

Identifiers

PMID41601701
PMCPMC12833374

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.