Evidence map›Paper›PMID 41601757›Full record

ArticleFrontiers in medicine2025

Clinical characteristics and outcomes in 50 children with autoimmune hepatitis: a retrospective study from a single centre in China.

Yandi Yang, Fan Yang, Min Yang, Zherui Liu, Shuhong Liu, Linlin Lian, Binxia Chang, Lijun Shen, Hua Tian, Qingsheng Liang and 8 more

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yandi Yang *The 82nd Group Army Hospital of PLA, Baoding, Hebei, China.
Fan Yang *Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Min Yang *Department of Preventive Medicine, Hubei University of Chinese Medicine, Wuhan, China.
Zherui LiuPeking University 302 Clinical Medical School, Beijing, China.
Shuhong LiuDepartment of Pathology and Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, China.
Linlin LianHandan City Infectious Disease Hospital, Handan, Hebei, China.
Binxia ChangSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Lijun ShenSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Hua TianSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Qingsheng LiangSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Songhai ChenSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Shuna DongThe 989 Hospital of the People's Liberation Army Joint Service Support Force, Luoyang, China.
Chunyu LiThe 82nd Group Army Hospital of PLA, Baoding, Hebei, China.
Huan XieSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Yan ZhongYunnan University, Kunming, China.
Zhengsheng ZouSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Ying SunSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.
Yun ZhuSenior Department of Hepatology, Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Little is known about autoimmune hepatitis (AIH) in Chinese children. The study aimed to explore the clinical characteristics and predictors of outcomes in the Chinese paediatric AIH cohort. Methods: A retrospective review of all paediatric AIH cases from 2015 to 2025 was conducted at a single centre in Beijing, China. Results: Of the 50 enrolled cases, 39 (78.0%) presented with type 1 AIH (consisting of 30 female children (60.0%); median age of 9.2 years). At presentation, 24 (48.0%) patients had cirrhosis, 11 (22.0%) had liver failure, and 10 (20.0%) had decompensated cirrhosis at presentation. Compared to type 1, children with type 2 were younger and had higher levels of serum alanine aminotransferase [270.0 (166.0, 599.0) U/L vs. 610.0 (510.0, 1231.0) U/L, Conclusion: The majority of paediatric AIH patients survive with a native liver, and the outcome is not related to the type of immunosuppressive therapies but to decompensated cirrhosis at presentation.

Indexed as

autoimmune hepatitischildrenoutcometreatmenttype

Identifiers

PMID41601757
PMCPMC12833044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.