ArticleFrontiers in medicine2025
Multimodal imaging for early drusen detection: RM-SLO as a promising imaging approach.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Purpose: This study aimed to evaluate the diagnostic performance of retro-mode scanning laser ophthalmoscopy (RM-SLO) in detecting drusen compared to conventional multimodal imaging. Additionally, it sought to explore the imaging characteristics of RM-SLO for early age-related macular degeneration (AMD). Methods: In this cross-sectional study, 192 patients (263 eyes) were examined using color fundus photography (CFP), optical coherence tomography (OCT), fundus fluorescein angiography (FFA), fundus autofluorescence (FAF), and RM-SLO. Three retinal specialists independently reviewed all images for the presence of drusen. Detection rates across modalities were compared using Cochran's Q-test, and imaging characteristics of hard and soft drusen were described. Results: RM-SLO detected drusen in 102 eyes (38.78%). This detection rate was significantly higher compared to other methods such as OCT (22.05%), CFP (8.37%), FFA (5.32%), and FAF (4.18%) (all Conclusion: RM-SLO demonstrates superior sensitivity and imaging clarity for drusen detection compared to conventional multimodal approaches. Its ability to visualize small and morphologically distinct drusen highlights its potential as a promising tool for early AMD screening and clinical management.
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