SynthesisFrontiers in endocrinology2025
Association of metabolic dysfunction-associated steatotic liver disease with bone health in adults: a systematic review and meta-analysis of observational studies.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Integrative Single-Cell Transcriptomic, Mendelian Randomization and In Silico Perturbation Analyses Prioritize MUC20 as a Candidate Gene Associated with Osteoporosis and Metabolic Dysfunction-Associated Steatotic Liver Disease in the Liver-Bone Axis.International journal of molecular sciences · 2026Article
- Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and osteoporosis in type 2 diabetes with MASLD.Asia Pacific journal of clinical nutrition · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Several studies have explored the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on bone mineral density (BMD) and bone turnover markers (BTMs) in adults and the risk of osteoporotic fractures. However, the extent of adverse effects of MASLD on bone health remains uncertain. This systematic review and meta-analysis aimed to investigate the effects of MASLD on bone health in adults. Methods: We searched PubMed, Medline, EMBASE, Cochrane Library, and Scopus for observational studies published from inception to June 2025 that reported MASLD effects on bone health. Results: This meta-analysis indicated that MASLD was associated with increased femur BMD (WMD: 0.03 g/cm Conclusions: MASLD was significantly associated with increased femur BMD compared to non-MASLD patients, especially in women and overweight individuals. Interestingly, increased risk of OP/osteoporotic fractures and decreased BTMs were significantly associated with MASLD. This may suggest that BMD underestimates the risk of OP/osteoporotic fractures in MASLD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.