SynthesisFrontiers in endocrinology2025
Association between the neutrophil-to-lymphocyte ratio and the incidence of diabetic retinopathy: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Serum Albumin as a Marker of Microvascular Burden in Diabetic Retinopathy: Mediation by Diabetic Nephropathy in Uncontrolled Diabetes.Journal of ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Accumulating evidence has indicated a possible relation of the neutrophil-to-lymphocyte ratio (NLR) to diabetic retinopathy (DR) incidence. However, current findings remain inconclusive. Methods: PubMed, Embase, Web of Science, as well as Cochrane Library, were thoroughly retrieved before March 20, 2025, for eligible studies examining the relation of NLR to DR incidence. The primary outcomes included DR incidence assessed as a categorical and a continuous variable. Categorical data were expressed as odds ratios (ORs) with 95% confidence intervals (CIs), and continuous data were expressed as standardized mean differences (SMDs) with 95% CIs. Results: 35 studies comprising 49,664 patients were encompassed. Pooled results demonstrated a significant relation between elevated NLR level and a greater DR risk, when analyzed as a categorical variable (OR = 1.48, 95% CI: 1.34-1.64; Conclusions: An increased NLR may be significantly related to a greater risk of DR among individuals with diabetes. However, further prospective and multicenter investigations are necessary to corroborate these findings. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=1054742, identifier CRD420251054742.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.