ArticleFrontiers in pharmacology2025
Association of medication regimen complexity index with ADRs in HIV/AIDS patients: a retrospective cohort study.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Identifying risk factors for adverse drug reactions in HIV/AIDS patients using LASSO regression modeling.BMC infectious diseases · 2026Article
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7 authors.
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Abstract
Purpose: To investigate the correlation between the medication regimen complexity index (MRCI) and adverse drug reactions (ADRs) among acquired immunodeficiency syndrome (AIDS) patients in the Chinese population. Introduction: The complexity of antiretroviral therapy (ART) regimens in individuals living with human immunodeficiency virus (HIV) presents significant challenges to medication management. To date, no studies have investigated the correlation between the MRCI and ADRs. Methods: This study retrospectively enrolled 1,010 patients. The MRCI was utilized to quantify the complexity of pharmacological treatment regimens. All suspected ADRs were assessed for causality using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) system. Univariate and multivariate logistic regression analyses were conducted to identify risk factors associated with ADRs and MRCI. Results: Our findings demonstrate that the MRCI significantly increased from 4.09 ± 4.04 pre-admission to 6.09 ± 6.05 at discharge ( Conclusion: In China, the MRCI of HIV/AIDS patients significantly increased after hospitalization. Further analysis indicates that patients with higher MRCI are more likely to experience ADRs.
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