Evidence map›Paper›PMID 41602117›Full record

ArticleFrontiers in cellular and infection microbiology2025

Fenofibrate suppresses

Maolin Xu, Tian Wang, Xian Deng, Yuxin Liu, Zimeng Zhu, Herman W Barkema, Eduardo R Cobo, John P Kastelic, Xueying Zhou, Bo Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maolin XuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Tian WangCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Xian DengCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Yuxin LiuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Zimeng ZhuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Herman W BarkemaFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Eduardo R CoboFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
John P KastelicFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Xueying ZhouCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Bo HanCollege of Veterinary Medicine, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: We evaluated effects of fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, on Results: Fenofibrate enhanced autophagic flux via upregulation of LC3B and LAMP2, promoted nuclear translocation of TFEB and TFE3, and reduced intracellular cholesterol by repressing 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGCR) and Sterol Regulatory Element-Binding Transcription Factor 2 (SREBF2) while increasing Acetyl-Coenzyme A Acetyltransferase 1 (ACAT1) expression. Based on confocal imaging, fenofibrate disrupted co-localization between Conclusion: Fenofibrate enhanced defense capability of mammary epithelial cells against

Indexed as

AutophagyCholesterolEpithelial CellsFenofibrateMammary Glands, AnimalMycoplasma bovisMycoplasma InfectionsAnimalsCattleDisease Models, AnimalFemaleMastitis, BovineMiceSterol Regulatory Element Binding Protein 2CholesterolFenofibrateSterol Regulatory Element Binding Protein 2autophagycholesterol metabolismfenofibrateintracellular infectionMycoplasma bovis

Identifiers

PMID41602117
PMCPMC12833329

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.