Evidence map›Paper›PMID 41602158›Full record

ArticleFrontiers in molecular neuroscience2025

Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization.

Pengtian Zhao, Wenlu Yuan, Jiayi Zhang, Erke Gao, Dejing Zhang, Zhuolin Wu, Yue Zhang, Junbo Chen, Dunxu Hu, Baoyou Fan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pengtian Zhao *Department of Orthopedics, Tianjin First Center Hospital, Tianjin Medical University, Tianjin, China.
Wenlu Yuan *Department of Orthopedics, National Spinal Cord Injury International Cooperation Base, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China.
Jiayi Zhang *College of Life Science, Nankai University, Tianjin, China.
Erke GaoDepartment of Orthopedics, Tianjin First Center Hospital, Tianjin Medical University, Tianjin, China.
Dejing ZhangDepartment of Spine Surgery, Shengli Oilfield Central Hospital, Dongying, Shandong, China.
Zhuolin WuDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Yue ZhangDepartment of Orthopedics, National Spinal Cord Injury International Cooperation Base, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China.
Junbo ChenDepartment of Orthopedics, Tianjin First Center Hospital, Tianjin Medical University, Tianjin, China.
Dunxu HuDepartment of Pain Management, The Second Qilu Hospital of Shandong University, Jinan, Shandong, China.
Baoyou FanDepartment of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.
Junjin LiDepartment of Orthopedics, National Spinal Cord Injury International Cooperation Base, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China.
Wenchao DaiDepartment of Orthopedics, National Spinal Cord Injury International Cooperation Base, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China.
Zhijian WeiDepartment of Orthopedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Advanced Medical Research Institute, Shandong University, Jinan, Shandong, China.
Tao ZhangDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Spinal Cord Injury (SCI) is a severe central nervous system disorder that initiates inflammatory reactions, exacerbating tissue damage and impeding neuronal repair. Macrophage polarization plays a critical role in this pathological process: it significantly regulates inflammation resolution and tissue regeneration, rendering its modulation a key strategy for SCI repair. Omaveloxolone (Omav), a novel Nrf2 activator, has demonstrated potential in regulating inflammatory responses, suggesting it may serve as a promising candidate for SCI intervention. Methods: To evaluate the efficacy and underlying mechanism of Omav in SCI repair, a spinal cord contusion model was established in animal subjects. Additionally, an Results: Conclusion: Our results collectively confirm the efficacy of Omav in repairing spinal cord injury by targeting macrophage polarization and regulating inflammatory responses. This study not only highlights the therapeutic potential of Omav for SCI but also provides a novel pharmacological strategy for SCI treatment.

Indexed as

acute inflammationmacrophageneuroimmunologyOmaveloxolonespinal cord injury

Identifiers

PMID41602158
PMCPMC12833412

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.