Evidence mapPaperPMID 41602176Full record

ReviewRSC advances2026

Self-assembling nanocomposites for smart drug delivery: towards personalized and stimuli-responsive therapeutics.

Reza Emadi, Zahra Amiri, Fatemeh Mortazavi Moghadam, Setareh Raoufi, Mahtab Zargar Moradi, Sepideh Asadi, William C Cho, Jin Hee Park, Anahita Voosough, Marzieh Ramezani Farani and 2 more

Abstract readReview
In one paragraph

Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Reza EmadiDepartment of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran Tehran Iran Reza.emadi2020@gmail.com.
Zahra AmiriDepartment of Medical Nanotechnology, School of Medicine, North Khorasan University of Medical Sciences Bojnurd 94149 Iran zahra.amiri.de@gmail.com.
Fatemeh Mortazavi MoghadamDepartment of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran Iran fatimamortazavi@ut.ac.ir.
Setareh RaoufiDepartment of Drug Sciences, University of Pavia Via Taramelli 12 27100 Pavia Italy Setareh.raoufi01@universitadipavia.it.
Mahtab Zargar MoradiDepartment of Molecular Genetics, Faculty of Biological Sciences, Islamic Azad University Science and Research Branch Tehran Iran mahtab99do@gmail.com.
Sepideh AsadiDepartment of Nanobiotechnology and Biomimetics, School of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran Tehran Iran sepide.asadi.95@gmail.com.ORCID https://orcid.org/0000-0003-0400-5071
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital Hong Kong SAR China williamcscho@gmail.com.ORCID https://orcid.org/0000-0003-4174-4586
Jin Hee ParkNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University Incheon 22212 Republic of Korea wls0675@naver.com farani.marzi@inha.ac.kr h3418kr@inha.ac.kr yunsuk.huh@inha.ac.kr.
Anahita VoosoughFaculty of Biology, College of Science, University of Tehran Tehran Iran voosough.anahita@ut.ac.ir.
Marzieh Ramezani FaraniNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University Incheon 22212 Republic of Korea wls0675@naver.com farani.marzi@inha.ac.kr h3418kr@inha.ac.kr yunsuk.huh@inha.ac.kr.ORCID https://orcid.org/0000-0002-4184-5670
Seung-Kyu HwangNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University Incheon 22212 Republic of Korea wls0675@naver.com farani.marzi@inha.ac.kr h3418kr@inha.ac.kr yunsuk.huh@inha.ac.kr.ORCID https://orcid.org/0000-0002-8463-5147
Yun Suk HuhNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University Incheon 22212 Republic of Korea wls0675@naver.com farani.marzi@inha.ac.kr h3418kr@inha.ac.kr yunsuk.huh@inha.ac.kr.ORCID https://orcid.org/0000-0003-1612-4473

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembling nanocomposites (SANCs) represent a valuable and innovative drug delivery system that facilitates site-specific and stimulus-controlled drug administration. These composites have the capability to self-assemble into stimulus-responsive nanostructures, enabling the effective delivery of a wide range of therapeutic agents, from small molecules to biologics, to specific target sites. This advancement addresses crucial challenges in treating diseases like cancer and chronic inflammatory conditions. In this review, we briefly outline the advantages of SANCs in enhancing bioavailability, reducing systemic toxicity, and maintaining stability under physiological conditions. However, several significant obstacles remain, including challenges related to scalability, stability, storage, biocompatibility, and regulatory approvals that have not been met to obtain clinical applications. Furthermore, we explore the stimuli-responsive and biohybrid materials, as well as the integration of SANCs with artificial intelligence and nanotechnology to create intelligent drug delivery systems. Encouraging contributions for papers that emphasize the role of SANCs in personalized medicine, this review underscores the potential of these nanosystems in developing tailored, patient-specific treatment approaches. By establishing robust policy frameworks and fostering strategic partnerships, SANCs have the potential to usher in a new era of tailored solutions for delivering medications effectively, thereby advancing the field of modern medicine.

Identifiers

PMID41602176
PMCPMC12834095

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.