ArticleRSC advances2026
Insights into the colloidal and structural stability of Atezolizumab with nonpolar amino acid-based ionic liquids under multiple stresses: phase two.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
Monoclonal antibodies (mAbs) are susceptible to physical and chemical instabilities, which compromise their therapeutic efficacy and shelf life. This study investigates the potential of renewable choline-amino acid-based ionic liquids (Ch-AA ILs), specifically choline valinate (CV) and choline glycinate (CG), to enhance the stability of the aglycosylated IgG1 antibody, Atezolizumab (Amab). Amab was formulated in varying concentrations of the ionic liquids (ILs) and subjected to ambient, thermal (40-70 °C), and chemical (urea) stress conditions. Stability was assessed using Dynamic Light Scattering (DLS) to measure the hydrodynamic diameter (
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Registered trials
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