ArticleFrontiers in cardiovascular medicine2025
Clinical outcomes of FFR and IVUS-guided PCI in patients with myocardial bridging and proximal LAD stenosis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Intravascular ultrasound-guided percutaneous treatment of late-presenting left anterior descending artery compression after penetrating cardiac trauma in a young adult: a case report.European heart journal. Case reports · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Myocardial bridging (MB), once considered benign, is increasingly recognized for its role in myocardial ischemia, especially when coexisting with proximal left anterior descending (LAD) artery stenosis. Optimal revascularization strategies remain uncertain for such dual pathology. This study assessed whether a fractional flow reserve (FFR)-guided and intravascular ultrasound (IVUS)-optimized percutaneous coronary intervention (PCI) approach improves outcomes in this population. Methods: In this retrospective single-center study, 238 patients with moderate MB and proximal intermediate LAD stenosis were enrolled. Patients were stratified based on FFR measurements: those with FFR > 0.80 received medical therapy alone ( Results: Patients undergoing PCI (FFR ≤ 0.80) had significantly lower MACE rates than those managed conservatively (7.7% vs. 18.8%, Conclusions: An FFR-guided, IVUS-supported PCI strategy improves clinical outcomes in patients with MB and proximal LAD stenosis, particularly when avoiding stent placement in dynamically compressed MB segments. Procedural planning using IVUS and careful lesion assessment is essential. Functional evaluation alone may underestimate ischemia in MB; integration of anatomical and diastolic functional indices is recommended.
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