ArticleFrontiers in cardiovascular medicine2025
Association between Body Roundness Index and diastolic function in middle-aged and older adults: a cross-sectional study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diastolic dysfunction (DD) represents an early indicator of cardiac impairment and is strongly linked to adverse cardiovascular outcomes. While obesity-related indices have been associated with DD, the role of Body Roundness Index (BRI)-a novel adiposity measure reflecting body shape-remains unclear. This study aimed to evaluate the association between BRI and diastolic function in a community-based cohort. Methods: This cross-sectional analysis included 1,466 participants from the Longitudinal Investigation of Osteoarthritis and Cardiovascular Health Status cohort. BRI was calculated using a validated formula, and DD was assessed via echocardiographic parameters. BRI's optimal cutoff was derived via 1000-iteration bootstrap ROC analysis. Multivariable regression models were used to evaluate associations, adjusting for age, sex, blood pressure, lipid profile, and cardiovascular comorbidities. Results: Higher BRI was significantly associated with increased odds of DD. In fully adjusted logistic regression, each 1-unit increase in BRI was associated with 14.4% higher odds of DD (OR = 1.144, 95% CI: 1.046-1.251, Conclusions: BRI is nonlinearly and independently associated with impaired diastolic function in middle-aged and older adults, with modest diagnostic performance. These findings provided evidence on the link between body shape metrics and DD.
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