Evidence map›Paper›PMID 41602364›Full record

ArticleFrontiers in oncology2025

LncRNA DANCR promotes ABL2-mediated metastasis via decoying of miR-125a-5p in high-risk neuroblastoma.

Mingyou Gao, Fang Cao, Junling Li, Jun Zhang, Yuren Xia, Xiangdong Tian, Jie Li, Daowei Wang, Lin Lu, Yan Guo and 3 more

Abstract read
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In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingyou Gao *Department of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Fang Cao *Department of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Junling LiDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Jun ZhangDepartment of Thoracic Surgery, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China.
Yuren XiaDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Xiangdong TianDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Jie LiDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Daowei WangDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Lin LuDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yan GuoDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yuanyuan LiuDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Qiang ZhaoDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yun LiuDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with high-risk neuroblastoma preferentially present with widespread metastasis and often relapse despite intensive therapy, which is the major cause of death of patients with this cancer. Consequently, identifying the molecular drivers of neuroblastoma metastasis holds significant clinical importance. Methods: High-throughput sequencing analysis was performed to evaluate gene expression in neuroblastoma patients. Results: High-throughput sequencing analysis revealed that the long noncoding RNA DANCR was significantly upregulated in high-risk neuroblastoma patients, and its expression correlated with poor prognosis. Conclusion: In summary, our findings delineate the DANCR/miR-125a-5p/ABL2/cofilin axis as a critical regulator of cytoskeletal dynamics in neuroblastoma metastasis, offering novel insights for the diagnosis and therapeutic targeting of high-risk neuroblastoma.

Indexed as

ABL2cytoskeletonDANCRmetastasisMiR-125a-5pneuroblastoma

Identifiers

PMID41602364
PMCPMC12832256

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.