Evidence map›Paper›PMID 41602419›Full record

ArticleFrontiers in oncology2025

HIF-2α accumulation in human monocytes upon transfer of hypoxia-associated miRNAs via plasma-derived small extracellular vesicles from head and neck cancer patients.

Marie-Nicole Theodoraki, Linda Hofmann, Helen Bauer, Jonas Fleckner, Reinhard Depping, Christian Idel, Kirstin Plötze-Martin, Zuzana Penxova, Dirk Rades, Thomas K Hoffmann and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Niches in cancer: from primary tumors to metastatic disease.Journal of hematology & oncology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marie-Nicole Theodoraki *Department of Otorhinolaryngology, Ulm University Medical Center, Ulm, Germany.
Linda Hofmann *Department of Otorhinolaryngology, Ulm University Medical Center, Ulm, Germany.
Helen BauerDepartment of Otorhinolaryngology, Ulm University Medical Center, Ulm, Germany.
Jonas FlecknerDepartment of Otorhinolaryngology, University of Luebeck, Luebeck, Germany.
Reinhard DeppingInstitute of Physiology, Working Group Hypoxia, University of Luebeck, Luebeck, Germany.
Christian IdelDepartment of Otorhinolaryngology, University of Luebeck, Luebeck, Germany.
Kirstin Plötze-MartinDepartment of Otorhinolaryngology, University of Luebeck, Luebeck, Germany.
Zuzana PenxovaDepartment of Otorhinolaryngology, University of Luebeck, Luebeck, Germany.
Dirk RadesDepartment of Radiation Oncology, University of Luebeck, Luebeck, Germany.
Thomas K HoffmannDepartment of Otorhinolaryngology, Ulm University Medical Center, Ulm, Germany.
Karl-Ludwig Bruchhage *Department of Otorhinolaryngology, University of Luebeck, Luebeck, Germany.
Ralph Pries *Department of Otorhinolaryngology, University of Luebeck, Luebeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia is an important hallmark of the tumor microenvironment (TME) in solid tumors and is closely associated with resistance to radiotherapy and a poorer clinical outcome. Tumor-associated plasma-derived small extracellular vesicles (sEVs) have gained increasing attention as an important regulatory TME component for tumor progression and immune evasion. This study aimed to investigate the involvement of plasma-derived sEVs from head and neck squamous cell carcinoma (HNSCC) patients in the systemic regulation of hypoxia-related molecular pathways in circulating immune cells. Plasma-derived sEVs of healthy donors (HDs) and HNSCC patients were isolated and evaluated for morphology, size, miRNA cargo composition, and their influence on monocyte characteristics. Transfer of plasma-derived sEVs from HNSCC patients stimulated increased levels of checkpoint molecule PD-L1 and chemokine CXCL4 secretion. An accumulation of hypoxia-inducible factor (HIF)-2α was associated with hypoxia-regulating miRNAs in sEVs from HNSCC patients. This provides new insights into a proposed tumor-associated systemic sEV-miRNA-mediated hypoxia transfer.

Indexed as

HIF-2αHNSCChypoxialiquid biomarkermiRNAmonocytessmall extracellular vesicles

Identifiers

PMID41602419
PMCPMC12833699

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.