ReviewFrontiers in bioengineering and biotechnology2025
Chemical analysis of extracellular vesicles by synchrotron-based X-ray imaging and scattering techniques: a review and perspective.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs) are nanoscale lipid bilayer-enclosed particles released by cells, which have been explored as pivotal mediators for intercellular communication, biomarkers for diseases and nano-carriers for drug delivery. Unraveling their structural and chemical heterogeneity is crucial for understanding the biogenesis, cargo sorting, and functional mechanisms of EVs. However, by far it remains challenging to characterize the intrinsic physicochemical properties of EVs due to their varied intracellular origins, poly-disperse size distribution and dynamic membrane organization. Conventional imaging and light scattering methods either lack the chemical sensitivity or suffer from labeling artifacts. Here in this review, we summarize research work using synchrotron-based X-ray imaging and scattering techniques to resolve the chemical structural complexity of EVs with intrinsic chemical specificity and enhanced sensitivity. The feasibility and effectiveness of X-ray imaging and scattering tools on quantifying critical structural parameters of EVs including morphology, core-shell and bilayer structure is discussed. We hope it will inspire future in-depth work to bridge the gap between structural and biological functionality in EVs research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.