Evidence map›Paper›PMID 41602788›Full record

ArticleAdvances in redox research2025

Dietary metal chelator, phytochelatin 2, increases selenium and alters metal homeostasis and associated lipid metabolism in the liver.

Zachery R Jarrell, Ho Young Lee, Choon-Myung Lee, Michael L Orr, Dean P Jones, Young-Mi Go

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in redox research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachery R JarrellDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0003-4670-1497
Ho Young LeeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.
Choon-Myung LeeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.
Michael L OrrDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.
Dean P JonesDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.
Young-Mi GoDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0003-3353-0844

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Melanie Alice PEARSON · 2013 to 2026
$22.6M
Cadmium-potentiated metabolic reprogramming in pathogenesis of lung fibrosisR01ES031980 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI · 2021 to 2025
$2.2M
Dietary phytochelatins and their impact on cadmium toxicity in the male reproductive systemF32ES033908 · NIEHS · EMORY UNIVERSITY · PI JARRELL, ZACHERY RYAN · 2022 to 2023
$101k
NIEHS NIH HHS F32 ES033908NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES031980
6 · The paper itself

Abstract

Biological systems have evolved highly regulated systems to ensure homeostatic levels of trace minerals, such as selenium (Se), which are important to metabolic function and signaling. Much of the understanding of these systems is limited to endogenous proteins and small molecules used for trafficking of minerals. Phytochelatins, a class of plant-derived metal chelating peptides with the general structure, (γ-Glu-Cys)

Indexed as

MetabolomicsMetallomicsNutritionPyC, Trace metals

Identifiers

PMID41602788
PMCPMC12834553

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.