In one paragraphArticle in Circulation. Genomic and precision medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
25 authors.
Naman S ShettyDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (N.S.S.).ORCID 0000-0003-3600-126X Akhil PampanaDivision of Cardiovascular Disease (A.P., A.N., H.S.B., N.P., N.V., G.A., P.A.), University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-4167-0540 Mokshad GaonkarDepartment of Biostatistics (M.G.), University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-0309-6813 Amrita NayakDivision of Cardiovascular Disease (A.P., A.N., H.S.B., N.P., N.V., G.A., P.A.), University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-9522-4717 Harshvir S BalDivision of Cardiovascular Disease (A.P., A.N., H.S.B., N.P., N.V., G.A., P.A.), University of Alabama at Birmingham, Birmingham, AL.
Nirav PatelDivision of Cardiovascular Disease (A.P., A.N., H.S.B., N.P., N.V., G.A., P.A.), University of Alabama at Birmingham, Birmingham, AL.
Nehal VekariyaDivision of Cardiovascular Disease (A.P., A.N., H.S.B., N.P., N.V., G.A., P.A.), University of Alabama at Birmingham, Birmingham, AL.ORCID 0009-0002-3372-8375 J Gustav SmithThe Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine and Science for Life Laboratory, Gothenburg University, Sweden (J.G.S.).ORCID 0000-0001-6285-9935 Alanna C MorrisonHuman Genetics Center, University of Texas Health Science Center, Houston (A.C.M., B.Y., E.B.).ORCID 0000-0001-6381-4296 Bing YuHuman Genetics Center, University of Texas Health Science Center, Houston (A.C.M., B.Y., E.B.).ORCID 0000-0003-4818-1077 Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Systems and Population Health, University of Washington, Seattle (B.M.P., J.S.F.).ORCID 0000-0002-7278-2190 Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center, Houston (A.C.M., B.Y., E.B.).ORCID 0000-0001-8813-0544 James S FloydCardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Systems and Population Health, University of Washington, Seattle (B.M.P., J.S.F.).ORCID 0000-0002-0365-9041 Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T., X.G.).ORCID 0000-0001-7191-1723 Kent D TaylorDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T., X.G.).ORCID 0000-0002-2756-4370 Leslie A LangeDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora (L.A.L.).
Marguerite R IrvinDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham (M.R.I.).ORCID 0000-0002-1442-2023 Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington (M.C.).ORCID 0000-0002-7871-6143 Thomas J WangDepartment of Medicine, University of Texas-Southwestern Medical Center, Dallas (T.J.W.).ORCID 0000-0003-4063-6508 Xiuqing GuoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T., X.G.).ORCID 0000-0002-5264-5068 Garima AroraDivision of Cardiovascular Disease (A.P., A.N., H.S.B., N.P., N.V., G.A., P.A.), University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-6402-6910 Pankaj AroraDivision of Cardiovascular Disease (A.P., A.N., H.S.B., N.P., N.V., G.A., P.A.), University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-2420-3550 Funding
Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood PressureR01HL160982 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.7MAtrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological StudyR01HL163081 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.7MThe Effects of Neprilysin Inhibition on Cardiometabolic Health in Black IndividualsR01HL163852 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.6MClinical Implementation of Blood Pressure Polygenic Risk Score: A Randomized Clinical TrialR01HL176882 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2025 to 2026
$1.5MMentored Patient-Oriented Research in Natriuretic Peptide System Based Precision Cardiometabolic HealthK24HL180320 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2025 to 2026
$265kNHLBI NIH HHS K24 HL180320NHLBI NIH HHS R01 HL160982NHLBI NIH HHS R01 HL163081NHLBI NIH HHS R01 HL163852NHLBI NIH HHS R01 HL176882
6 · The paper itselfAbstract
backgroundNPs (natriuretic peptides) are bioactive hormones crucial for regulating blood pressure, glucose homeostasis, and lipid metabolism. Despite the high heritability of circulating NP levels, the genetic determinants of NP regulation, particularly across ancestries and sexes, remain poorly understood. The objective of the current study was to identify genetic variants associated with NT-proBNP (N-terminal pro-B-type NP) levels in a multiancestry study population.
methodsWhole genome sequencing and array-based data from 81 213 individuals without heart failure were analyzed from the Trans-Omics for Precision Medicine cohorts, UK Biobank, All of Us Research Program, and REGARDS (Reasons for Geographic and Racial Differences in Stroke) study to identify common, rare, and structural variants associated with NT-proBNP levels. The main outcome of the study was rank-based inverse normal and standardized NT-proBNP levels. Genetic associations with NT-proBNP were examined, followed by gene prioritization, transcriptome-wide association studies, colocalization, and rare variant analyses.
resultsNine novel loci and 3 previously reported loci were identified to be associated with NT-proBNP levels. Novel structural variants were detected across 12 loci. Similar effect sizes were observed for both common and rare variants. Key genes such as
conclusionsThis study identifies novel common, rare, and structural variants associated with NT-proBNP levels, highlighting the contribution of both coding and regulatory non-coding variation. These findings advance our understanding of the genetic architecture of NT-proBNP and may inform future cardiometabolic therapeutic strategies.
Indexed as
Natriuretic Peptide, BrainPeptide FragmentsAgedFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)blood pressurecardiovascular diseasesgeneticsgenome-wide association studypeptidespolymorphism, single-nucleotidepro-brain natriuretic peptides
Identifiers
PMID41603044
PMCPMC13321388
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390