ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Metabolic Reprogramming at the Maternal-Fetal Interface: Insights from Decidual Stromal Cells and Trophoblasts in Healthy Pregnancy Versus Recurrent Pregnancy Loss.International journal of molecular sciences · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Mammalian placental metabolism is crucial for both placental and embryonic development. However, the metabolic profiles of placentas and their regulatory roles in placentogenesis and embryonic development at different developmental stages remain poorly characterized. To address these questions, we collect 501 mouse placentas spanning embryonic day (E) 8.5-14.5 and construct metabolomic-transcriptomic atlases of placentogenesis. Metabolomic and transcriptomic analyses reveal that placental samples from E8.5 to E14.5 are clustered into three separated states: E8.5, E9.5-10.5, and E11.5-14.5, pinpointing the metabolic transitions during placentogenesis from E8.5 to E9.5 and from E10.5 to E11.5. Based on a series of metabolite and enrichment analyses, Nicotinamide adenine dinucleotide (NAD(H)), flavin adenine dinucleotide (FAD), and L-glutamate (Glu) are identified as differentially abundant metabolites (DAMs) during E8.5-14.5. Using in vitro cultured (IVC) embryos, NAD(H) is shown to promote the extension of embryonic body length, through accelerated segmentation and increased proliferation, as verified in NAD(H)-treated mouse embryonic stem cell (mESC)-induced presomitic mesoderm (PSM)-like progenitor cells. These findings not only serve as an invaluable resource for understanding placental metabolism and its contribution to embryogenesis but also shed light on the mechanisms underlying developmental abnormalities associated with placental metabolic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.