Evidence map›Paper›PMID 41603369›Full record

ArticleeLife2026

Identifying regulators of associative learning using a protein-labelling approach in

Aelon Rahmani, Anna McMillen, Ericka Allen, Radwan Ansaar, Renee Green, Michaela E Johnson, Anne Poljak, Yee Lian Chew

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Proximity Labeling inBio-protocol · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aelon RahmaniFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0009-0007-8498-6901
Anna McMillenFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0009-0008-9655-3350
Ericka AllenFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0009-0001-4749-4509
Radwan AnsaarFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0009-0009-7429-3321
Renee GreenFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0009-0001-8287-1955
Michaela E JohnsonFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0000-0003-2653-3078
Anne PoljakBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0001-9953-1984
Yee Lian ChewFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0000-0001-6078-9312

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Australian Research Council DP220102511National Health and Medical Research Council GNT1173448NIH HHS P40 OD010440
6 · The paper itself

Abstract

The ability to learn and form memories is critical for animals to make choices that promote their survival. The biological processes underlying learning and memory are mediated by a variety of genes in the nervous system, acting at specific times during memory encoding, consolidation, and retrieval. Many studies have utilised candidate gene approaches or random mutagenesis screens in model animals to explore the key molecular drivers for learning and memory. We propose a complementary approach to identify this network of learning regulators: the proximity-labelling tool TurboID, which promiscuously biotinylates neighbouring proteins, to snapshot the proteomic profile of neurons during learning. To do this, we expressed the TurboID enzyme in the entire nervous system of

Indexed as

Association LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsLearningStaining and LabelingAnimalsMemoryNeuronsProteomicsCaenorhabditis elegans ProteinsC. eleganslearningmemoryneuroscienceproteinproximity labelling

Identifiers

PMID41603369
PMCPMC12851583

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.